ID A0A3P8YJW5_ESOLU Unreviewed; 906 AA.
AC A0A3P8YJW5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=CARD domain-containing protein {ECO:0000259|PROSITE:PS50209};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016411.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016411.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016411.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8YJW5; -.
DR Ensembl; ENSELUT00000025762.2; ENSELUP00000016411.2; ENSELUG00000016154.2.
DR GeneTree; ENSGT00390000007091; -.
DR Proteomes; UP000265140; LG11.
DR Bgee; ENSELUG00000016154; Expressed in head kidney and 13 other cell types or tissues.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47308; NUCLEAR GTPASE SLIP-GC; 1.
DR PANTHER; PTHR47308:SF1; NUCLEAR GTPASE SLIP-GC; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50209; CARD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 814..904
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 103545 MW; 4583DAEC75C645A2 CRC64;
MGPPSPEKMK SDGDDANKQR KKQKRSAASR TTEIFEKMKS DGDDANKQTK KQKRSAASRT
TEIFDCKKKT EVKKIMESLR SKLEKMTSTK LTNFLRNKFE TLEKDKKKIV GVFGKTGAGK
SSLINTILGE TKLLPSGDQG PCTSVMIQVE ANKTNDKYIA EIEFITVQEW EDELSSIFMA
RSWELGDDED MDDSNDDEDD EIITAFYGNV GRGKTLEELM DKRCFSNIPE FRSALKKCFL
CDTAEELSEN IRCFTRSDTQ NDAFEPQYWP LVKCITVKVP NSKDLLEHVV LVDLPGNGDC
NKSRDEMWKK FVGDCSAVWI VSDISRATSE KECWEILDST VSLFGNGGEC QSLSFICTKT
DVIEMNQKDA HTNILTRNKT TKKKVRDKFQ KQKEVKKHFS GVKDFFKVFT VSSKEYRKRK
HLEKEETEIP HLQEFLRNLN GHHTRTSDYI SGAYGILSLI QGAKNSNMTD SKELCQILEK
KLKDNLKSIG DSMDESWEVF DRCLSQGVQQ SEDSHEKLIN KVISPRGKKH GGYHKVVKSL
CKHDGIYKPK RKKNRGKEIN LNESLASCMR SSIDEEFKYF FPNDKWGPIR EQIENFTLEA
TSLIRDHPRW SLHLRFLKME ERELKAELIC ELRKKKKEIY FTLTKSIMDS MHSCYRRASL
HTGKDSLKRM KDEIHQHVKN VNIFRKAKDD MLVRLTKLKN FIVMQLQSKL ERSIEISLKT
PDSLIFPDDV TEDYNKIKKL MDCSSTVPFT SILDPQPTTT AFQSMSGNGK KHVQITAPID
PDPLNLQPAL FDSESNDLRG SECQVPTDAG TELNQLSDVA FVKKNRNALI QRVKMVDAIA
DDLLLHDMIQ DEMYEKISKG STTQEQMRIL IGAVQAGGRM STSAFCVALR TYEPPLVQDL
ESSSCL
//
