ID A0A3P8YKU0_ESOLU Unreviewed; 906 AA.
AC A0A3P8YKU0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Disks large homolog 1 {ECO:0000256|ARBA:ARBA00044189};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016485.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000016485.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000016485.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; A0A3P8YKU0; -.
DR Ensembl; ENSELUT00000025839.2; ENSELUP00000016485.2; ENSELUG00000016534.2.
DR GeneTree; ENSGT00940000164867; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000016534; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR015143; L27_1.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF5; DISKS LARGE HOMOLOG 1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF09058; L27_1; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..64
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 219..301
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 309..396
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 459..540
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 574..644
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 716..891
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 108..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 100883 MW; 5C2A83405FFFC4C0 CRC64;
MPVRKKDAQR ALSLLEDYRT KLNHTEDRQL RHSIQRVIDI FQSNLFQALI DIQEFYEVTL
LDNQKCVESP KVSEPMPPVN LWDFSSLQST TVTSDTLPSL STSIEKYRHH DEDASPPEQS
SPQLTDEGPG PELVQVAEKN LSQIENIHGY VAHVHISPMK QTDATPPSSP IIPVIPMSPV
PAETTPVIPP PTSQANPPPV VVNTDSLDTP PYVSSTYLNG NSGLGFSIAG GTDNPHIGED
PSIFITKVIP GGAAAQDGRL RVNDVILRVN EADVRDVTHS RAVEALKEAG SLVRLYVRRR
KPLSEKLMEI KLVKGPKGLG FSIAGGVGNQ HIPGDNSIYV TKVIEGGAAH KDGRLQIGDK
LLAVNSACLE EVSHEHAVTA LKNTPDVVYL KVAKPNSVFM NDSFAPPDIT NSYSQHMENH
VSPPSYLGQP LPPAAPSGRY SPTPKSMLGE DDVTREPRKV VLHRGATGLG FNIVGGEDGE
GIFISFILAG GPADLCGELR KGDRLVSVNG VDLRSATHEQ AAAALKNAGQ TVTIVAHYRP
EEYSRFEAKI HDLREQMMNS SISSGSGSLR TSQKRSLYVR ALFDYDKTKD SGLPSQGLNF
KFGDILHVVN ASDDEWWQAR QVTLEGEAEE VGVIPSKRRV EKKERARLKT VKFNPKSRDR
GQSLNDKRKK NLFSRKFPFY NKNKDASEQE TSDVDRGQEE YVLSYEPVSQ QEVNYTRPVI
ILGPMKDRVN DDLISEFPDK FGSCVPHTTR PKRDYEVDTR DYHFVVSREQ MEKDIQDHKF
IEAGQYNNHL YGTSVQSVRE VAEKGKHCIL DVSGNAIKRL QLAQLHPIAV FIKPKSVENI
MEMNKRLTEE QGRKTFDRAT KLEHEFTEHF TAIVQGDTLE EIYEQVKQII EEQSGPFIWV
QSKEKL
//
