ID   A0A3P8YLE5_ESOLU        Unreviewed;       563 AA.
AC   A0A3P8YLE5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Lysyl oxidase homolog 1 {ECO:0000313|Ensembl:ENSELUP00000017369.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000017369.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000017369.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000017369.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|ARBA:ARBA00001935};
CC   -!- SIMILARITY: Belongs to the lysyl oxidase family.
CC       {ECO:0000256|ARBA:ARBA00007492}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_010876944.1; XM_010878642.3.
DR   RefSeq; XP_019907089.1; XM_020051530.1.
DR   AlphaFoldDB; A0A3P8YLE5; -.
DR   STRING; 8010.ENSELUP00000017375; -.
DR   Ensembl; ENSELUT00000026941.2; ENSELUP00000017369.1; ENSELUG00000017079.2.
DR   GeneID; 105015456; -.
DR   KEGG; els:105015456; -.
DR   GeneTree; ENSGT00940000161080; -.
DR   InParanoid; A0A3P8YLE5; -.
DR   OMA; SATPWRQ; -.
DR   OrthoDB; 3035117at2759; -.
DR   Proteomes; UP000265140; LG02.
DR   Bgee; ENSELUG00000017079; Expressed in nose and 12 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004720; F:protein-lysine 6-oxidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001695; Lysyl_oxidase.
DR   InterPro; IPR019828; Lysyl_oxidase_CS.
DR   PANTHER; PTHR45817:SF8; LYSYL OXIDASE HOMOLOG 1; 1.
DR   PANTHER; PTHR45817; LYSYL OXIDASE-LIKE-RELATED; 1.
DR   Pfam; PF01186; Lysyl_oxidase; 1.
DR   PRINTS; PR00074; LYSYLOXIDASE.
DR   PROSITE; PS00926; LYSYL_OXIDASE; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   LTQ {ECO:0000256|ARBA:ARBA00022477};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   TPQ {ECO:0000256|ARBA:ARBA00022772}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..563
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030079127"
FT   REGION          57..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          257..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..345
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  61697 MW;  9D09845079FD1D45 CRC64;
     MMMLPFVVGS LVWVLLGSGW AQVQDQTQAS TPWRQMIQWE NNGRRFSLLN SGAEYVPAGS
     QDQERSHRVV VADSRSRTPR RPQGGNVRRQ APSRGGSETV RGQTRHPFGF GQVPDNWRQG
     SVGTGSTSTR FRPSTGSSSS SSSSSSFSSS YNIPVQPYPQ FPFPQQPSYQ LPYDPSVVEG
     AGRGYAEPPF QRATGGGYSA GAGGYVGGGG GYAGVSYGAG AGLAPVVPRS PQDYGEDGYR
     YYPPYGYGPN PGAPVQPAVP ARAAQPPFSD GLDRRYTHSL YNGGEDSAAA ADTAPAAQDR
     TGAVAQAPVR SPQYEQFPPF GRPQVQPQPA APVRNPNTAV ENPSVNVGSV YRPEQRGLPD
     LVPDPNYVQA STYIQRAHMY SLRCAAEEKC LASTAYSAET TDYDVRVLLR FPQRVKNQGT
     ADFLPNRPRH TWEWHSCHQH YHSMDEFSHY DLLEVTTGRK VAEGHKASFC LEDTTCDFGH
     LKRYACTSHT QGLSPGCYDT YNADIDCQWI DITDIQPGNY ILKLQVNPKY LILESDFTNN
     VVRCNIHYTG RFVTTNNCKI SQS
//