ID   A0A3P8YLZ8_ESOLU        Unreviewed;      1049 AA.
AC   A0A3P8YLZ8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 3-like {ECO:0000313|Ensembl:ENSELUP00000016910.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000016910.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000016910.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000016910.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8YLZ8; -.
DR   Ensembl; ENSELUT00000026401.2; ENSELUP00000016910.2; ENSELUG00000016671.2.
DR   GeneTree; ENSGT01070000253760; -.
DR   InParanoid; A0A3P8YLZ8; -.
DR   OMA; TEMNIHF; -.
DR   Proteomes; UP000265140; LG23.
DR   Bgee; ENSELUG00000016671; Expressed in stomach and 12 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd08321; Pyrin_ASC-like; 1.
DR   CDD; cd16040; SPRY_PRY_SNTX; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR   PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00367; LRR_CC; 3.
DR   SMART; SM00368; LRR_RI; 5.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS51450; LRR; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          1..86
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          181..314
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          849..1044
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
SQ   SEQUENCE   1049 AA;  118759 MW;  5A19E49C9B299A2E CRC64;
     MAPVPELLLA ILEELVEVEL KTFKWHLTQD LLEGFPHIPV SQLEKADRLD TMKKIVETYG
     SGGAVKISQE ILKKMSQNQL AESLKNRCDV PETIELEVED KLKCYLRKKY GSIYEGTSRE
     GDFIYLNQVF TKLHVISGAW GGVTDEHEVM RLNIRTPAAE ETTVEVSNIF KQLPDQKKPM
     RTVLTQGIAG IGKSVSVQKF ILDWAEGKEN QGIHLVFPLP FRQINSNIGE DNCSLIELLH
     QFFPDMGPIK SLSNNSKVLF IFDGLDECRL PLDFSNKVLT DDTKPAPLDR LITNLITGEL
     LLDAQVWITT RPGAAKKIPR QYIHQWTEVR GFNDLQKEEY FRKKLWDVNL AGRIIAHMKS
     SRSLHILCHI PVFCWISATV LEKLLGEEES RKIPKTLTEM NIHFLLYQIG RMEVADNSTA
     RYNFILKLGE LAFRQLERGH LVFYEEDLTE CGIDFTEAAV NSSLCTEIFE VGRMSRKSVF
     SFVHLSIQEF LAAVYVFVTF INSEQNPLVK PNSIVKLLTW GKQQSMNDLF KNAVNQALHS
     ENGHLDLFLR FLLGLSIESN QTLLQGLLTQ KGKNTHTHEK IIEYIKKKIR RNESSERCIN
     LFHCLNELND HSLVEEIQMY LNSGNISEVK LSPAQWSSLV FVLLTSEEEL DVFDLKKYSK
     SEEGLLWMLP VIKSSRIAVL DGCNITGACC EALAPVLSST CSHLRELDLS NNDLQDSGVK
     LLAAGLGSPQ CKLKKLSLNG CNITERCCKE LTSALTTSNL RTLDLSNNKL QDSGVKLLCE
     GLANSQCRLK TLRLSFCGVT EEGCAALISA LRSNPSHLRD LDLSYNHPGE SGAKLLSAGL
     NDLIHKLQTL SVHPRGEGWL FRRLHWMDLT LNPDTANSFL SLSVGNRKVS HGKEWQPYTN
     HPERFTHWPQ VLCRECLTGR CYWEVEWSGK WALIGVTYRM FNITLKRRFG ANNKSWSLEC
     CGNRFSIWHS NKRMDLPVSS VSQSNRVGVY LDWPTGTLSF YSVSSETMIH LYTFNCAFAE
     PVYAGIGVSF QSSMTLCKVD TKDLQATKP
//