ID A0A3P8YN81_ESOLU Unreviewed; 2720 AA.
AC A0A3P8YN81;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Puratrophin-1 {ECO:0000313|Ensembl:ENSELUP00000018068.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018068.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018068.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018068.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSELUT00000027836.2; ENSELUP00000018068.2; ENSELUG00000018035.2.
DR GeneTree; ENSGT00940000158845; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000018035; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING, FAMILY G (WITH RHOGEF DOMAIN) MEMBER 4; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 2208..2385
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 2397..2505
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 135..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1968..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2023..2151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2184..2206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2628..2653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2674..2699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1311
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1439
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2023..2042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2084..2110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2119..2150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2188..2202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2634..2653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2720 AA; 302535 MW; 3198251F6AF1788D CRC64;
MFQYCGLLFR HQGWPLCLHD KVIIQLSSLD PSLLRPGDFY LQVAPPTPLV SNSTSPTLRP
PRIALCCLAP GGQYVEQQDV PQIAYPSLFS MAWLQSVNRE RCRAGSGRPL SHCLLSADND
IFRVPWEDVV HPEFITRPRT KDPAPARSPA KGEGDGDREQ DVIKPSDRDR DMLIDTSKAQ
YVDRGVAKEC WPLPRLGQPI KTSNNGKGFD ITAEEDSDLE GEYVELEDIL LPRFSPQKGS
LTESISLNYR NLHKPWTTPQ HMPLKATQTQ QHPKPTCLNA TLTQQPQEPT PLKATPTKHA
PRTAPVLPLH PLKNSSMSSQ FTVGSRLIEE NLNNYAFRPV ILTPAFPNSQ AFPTGEEGVS
SERAVPDRPT EVRNEGSAAA TGSHYFTQRV CDSVTGGTEV SALAETDTRI SQEDSSVKTE
ETDTRISQED SSVKTVETDT RIRQEDSSVK TVETDTRIRQ EDSSVKAEEM DTRIRQEDSS
VKTEEIDTRI SQEDSSVKTE EIDTRISQED SSVKTEEIDT RISQEDSSVK TEENDIRISQ
EDSSVKTEEN DIRISQEDNS VKTEETDTRI SQEDSSVKTE ENDIRISQED SSVKTEENDI
RISQEDNSVK TEETDTRISQ EDSSVKTEEK DPRIRQEDSS VKTEETDTRI SQEDSSVKTE
EKDPRIRQED SSVKTEETDT RISQEDSSVK TEEKDTSIRQ EDSSVKTEEK DTRIRQEDSP
VKKEETDSVL EEKEKKEEVE DKRKEDEVKD NNAPAIKETG DNHVGFSEEE VGIREVGLHS
DPLVEEQAPN TLLTHTPQTT NTPPADAHTH LARCPSMPES SEASTAETGS YPANCSPNQT
STTEEDTPAP IDSEKTQEEE RLGERGGDGE REKQQTGRRE NKGEDKRVER EEEEEGVDVS
LVDQTRTTQQ QVSQKDTGER GGKDVDGEEE GGEKDWEREE GKEEREKGVV DKGRVGEEEG
EVKREKAEFP GGQEETPVIR ESGGDASVEL SDNTHTSTDT YTHTTTDTHT HTETAGRLAT
PTARHSLETK RRAKEEREIE REEGKAGEKV RNIEQRPIQE DRIEEGEEGL SKDRVEGGNV
QESTKEIEEV KEKSLPLNFD PVDSVTEESD EDDGVDPRVC ESVPGPLLPP ALLTPLTHSE
YSTGSHTLHS VESSDDQRTH STTDTPSTEP EEQRLMEVEE EQKEVEGHHS ATETQEKEET
GVIQAEECVF SFCSMEKQPS SELINTKLEK SPTAMLQDPP LMLLQLATPP SPQLATPPLS
QLAPPVLPQL DPPPLSLLAP TPTPQLSPLP SHQLDPPPSP QLSPPLSQQL DPPPSHQLET
PSSPQLSPPL SQQLDPPPSP QLFPPLSQQL DPPPSHQLET PSSPQLSPPP SNQLSPPLSE
QLDPPPSPQL SPPISQQLDP PPSAQLSPPP SHQLDPPPSP QLSPPLSQQL DPPPSPQLSS
PLSQQLDPPQ LAPPLSPQLD QTPANLDHFN SQLSASPRSQ ILIEAHKIHP AVLSSGVLCL
PGTRDKGGRA LVTVTTRNTI WLNPNCNSGE LVRILVYFRT VLRKEVRSLG FTVLVDSRRC
SPVPALFKAF NILQDTMPGC IHTVLLLADR DLALRLDKPS AIQVELLTSL KSLHKHVEVS
QLPHDFQGTF PFSHSAWISF RMRLEQLTSH CEDAVNLLQS TIQNLEAIAL PHTAEEAQLL
LTRYRGVMRS VLEDGRLVKL QLEGGANLSR LRKEETSVSL TDDYRDAVEG VGSLYDRVDE
LVHRLVMLSN QRTQELEFVM EFKGLEQGFK EVTDWIVEVG ESRLSALGQL EDSLEQLHSK
KTLFRDFYSA AYEHCKGGEA LLKRLERWED LSSAELQVYE VKVRSFWVHL QDFSQRVEDT
KTNIDKTVRL YEFFDKAYEW ALEGMRHLAR VSMEDCTAPD KCHGVITCLE GYRCQHPPIP
DPHFQEMKEL AVELKSEQGL KQWKFAWSKC QETKQMFEKK LEAALRTGRA LASGDSPGSR
PVKAGGEQAE GVTPRRGGEG PERSGSVSYA CRKAFSGVWG GRERLSSTSS CASSQSTCSP
RQEAGGGDGC GASSPYRVPH TPLPSQRLTR STSSEESSHR ARMEAQARTT SCSFSHSLPP
MNSQSPSLTP GRRPPLRKTQ SFDCQSSSPS TPDSARYGTC QRTLSEPTRR GNTGVFIKGL
EVSSMEVADR SYSPRMASPV WAAGEAVRTP SASTTSSPVS EPRAKGSKLR HIVDEMVTTE
REYVRSLRYI IEHYFPEMER GDLPQDLRGK RSVIFGNLEK LVDFHSQYFL KELESCCNHP
LRVSHCFLRH QDQFGLYALY SKNKPKSDTL LASHGNSFFR NKQLELGDKM DLASYLLKPI
QRMSKYALLL KDLIKEVSEA QETELSYLRA AAEMVKFQLR HGNDLLAMDA IRDCDVNLKE
QGQLVRQDEF CIWYGRKKCQ RHVFLFEDLV LFSKPKRIEG GLDVYIYKHS FKTADVGMTE
TSGDNPLRFE VWFRRRTSKN QTYVLQASTA DIKNAWTANI ARILWQQATR NKEIRNQEMV
SMGVGNKPFL DIKPSDAAIN DRAIDYIMKG RGARTRASIA VSLFDHSNPF KRTASGNGGS
GGGAPTASGP SSCTLLGPLN LHMYSNHSQA LLPGGDRPFI SPCIEEDELE HETSSQPSMT
TESSGSSSHC LSGSGSSGSD SGCVSSHLPE PCLSEEPSSP CYPPSNAVTP PSLAQDKPRY
NNSQYISAKA AQIIGPATVV
//
