ID A0A3P8YNI8_ESOLU Unreviewed; 569 AA.
AC A0A3P8YNI8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rap1 GTPase-activating protein 2 {ECO:0000313|Ensembl:ENSELUP00000017421.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000017421.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000017421.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000017421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010883255.1; XM_010884953.2.
DR AlphaFoldDB; A0A3P8YNI8; -.
DR Ensembl; ENSELUT00000027039.2; ENSELUP00000017421.1; ENSELUG00000017118.2.
DR GeneID; 105019055; -.
DR GeneTree; ENSGT00940000166290; -.
DR InParanoid; A0A3P8YNI8; -.
DR OMA; RCEFPPP; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000017118; Expressed in head kidney and 8 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF1; RAP1 GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00390; GoLoco; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 239..459
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 517..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 63629 MW; 9761F707B2E1B365 CRC64;
MEGERNEKFI SRKRSFTFGA YGGVDNFICE NEMTKPEPLE HSILDILDSP TSESKPLLST
GNNQKVTELF EIIEKLQGSR LDEQRCAFPP PLRLLKIGGD LPLILPPKLG GYWIDPPLEK
FAETSPTSSH YGLQPESYDI MERDSEAKYY QEFFRSRYHH SFTAVDPSLG PLVLSVCLEE
EENRLRVILR IKECSMHGVF SVSLFPNIPS AVELAKMLCE SVTVPRFDVV SYLKAPDLIT
AFDEHRVSQN FKFGVLYQRE GQLTEEDILY NNEESEEFQE FLSILGETVT LQGFTGFRGG
LDVCHGQTGS DAVFTSFHGR EIMFHVATKL PFTEGDAQQL QRKRHIGNDI VAVVYQEGNT
PFLSDVISSH FLHCFLVVRR VRKGEGEEGG EGVFQVSVTA REDVPPFGPA LPDPPIFTHK
SLLREFLLTK LINAEISCYK AERFSRLELR TRSSLLEGLQ AELSSRSQCM MGDPPVSALF
SSEGVRGVTE GSGGFIENFK RAIRVRSYSF DTLGGPRKIG GVPLPQKPKA TTEKNGESES
YKSPGPSLPA SDIQGFTEVK DHSSPQEDT
//
