ID A0A3P8YNM5_ESOLU Unreviewed; 392 AA.
AC A0A3P8YNM5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Cytohesin 3 {ECO:0008006|Google:ProtNLM};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018213.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018213.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8YNM5; -.
DR Ensembl; ENSELUT00000028026.2; ENSELUP00000018213.1; ENSELUG00000000716.2.
DR GeneTree; ENSGT00940000155825; -.
DR Proteomes; UP000265140; LG05.
DR Bgee; ENSELUG00000000716; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF320; CYTOHESIN-3; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 52..239
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 257..373
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 14..51
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 392 AA; 45851 MW; 369D969C21CA83D3 CRC64;
MLMYLPEDLS LDERDELSNI RRRKRELLDD IERLKFEIAE VMTEIEQLTC VGESKTTQRN
KQIAMGRKKF NMDPKKGIQF LLENDLLQHT PEDISQFLYK GEGLNKTVIG DYLGERDEFN
LKVLQAFVEL HEFADLNLVQ ALRQFLWSFR LPGEAQKIDR MMEAFASRYC SCNPGVFQST
DTCYVLSFAI IMLNTSLHNP NVRDKPPVER FISMNRGINE GGDLPEELLR NLFDSIKNEP
FKIPEDDGND LTHTFFNPDR EGWLLKLGGR VKTWKRRWFI LTDNCLYYFE YTTDKEPRGI
IPLENLSIRE VEEPRKPNCF ELYNPNHKGS VIKACKTEAD GRVVEGNHTV YRISAPTTEE
KEEWIKSIKA SISRDPFYDM LATRKRRIAN KK
//
