ID A0A3P8YNY5_ESOLU Unreviewed; 2169 AA.
AC A0A3P8YNY5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Unconventional myosin-VIIa {ECO:0000313|Ensembl:ENSELUP00000018275.2};
GN Name=MYO7A {ECO:0000313|Ensembl:ENSELUP00000018275.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018275.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018275.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018275.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8010.ENSELUP00000018275; -.
DR Ensembl; ENSELUT00000028122.2; ENSELUP00000018275.2; ENSELUG00000017865.2.
DR GeneTree; ENSGT00940000155350; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000017865; Expressed in camera-type eye and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF34; MYOSIN VIIA; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 61..739
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1018..1258
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1263..1583
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1581..1651
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1707..1849
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1855..2158
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 614..636
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 860..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..994
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 154..161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2169 AA; 249917 MW; 475C93B7D24AF3F3 CRC64;
HLGDYVWLDL KTGREFDVPV GAVVKLCDSG QIQVLDDEGR EHWISPQNAT NIKPMHPTSI
HGVEDMIRLG DLNEAGILRN LLIRYNERVI YTYTGSILVA VNPYQLLPIY TPDQIRLYTN
KKIGEMPPHI FAIADNCYFN MQRNNKDQCC IISGESGAGK TESTKLILQF LAAISGQHSW
IEQQVLEANP ILEAFGNAKT IRNDNSSRFG KYIDIHFNKR GAIEGAKIEQ YLLEKSRVCR
QAADERNYHI FYCMLRGMAP ELKTKLGLGL ATDYTYLTMG NCTTCDGRDD LKEYSSILSA
MKVLMFTETE NWEISKLLAA ILHMGNLRFE ARTYDNLDAC LVIRSPDLST AASLMEVDPK
DVMSCLTTRT LITRGESVST PLSIEQGLDV RDAFVKGIYG RLFVWIVDKI NAAIFRPPSC
ESNIVRRSIG LLDIFGFENF IVNSFEQLCI NFANENLQQF FVRHVFKLEQ EEYNLEDINW
QHIEFTDNQD ALDMIANKPM NIISLIDEES KFPKGTDATM LYKLNSQHKL NTNYHPPKNT
YGTQFGIQHF AGVVHYETKG FLEKNRDSLH TDIIQLVHSS KNKFIKQIFQ ADVAMGVETR
KRSPTLSSQF KRSLELLMRT LNVCQPFFVR CIKPNELKKP MIFDPLQELC VRQLRYSGMM
ETIRIRRAGY PIRYTFGEFV DRYRVLMPGV KPANRQDDLR GTCQKIVEAV LGRDDDWQIG
KTKIFLKDHH DMQLEIERDK AITDKVILIQ KAVRGMKDRA NFLRLRRSVT LIQKMWRGYR
CRKDYSAMRV GFLRLQALYR SRKLFVTYRL AKTRITQMQA RCRGFMVRRS FWRQLHAVVT
IQAYTRGMIA RRVTQRLRAE HRRRQEAESQ RLAEEERLRN QMTARRARAE AEKSHKERLA
ELARQEEQRE KEAREEARRK KEMVEQLERE KQQPVDHSDM VDQMFGFLGN TGTLPNLEGQ
GPSGFEDLEV AHRAEEEEEE KEEEEAIPLP DEEEEDLSEY KFSKFAATYF QGTTTHTYLR
RPLKQPLLFH EDEGDQLAAL AVWITVMRFM GDLPEPKYHI TISDGSEKIP VMTKIYETLG
KRTYKRELQE LQTMEGENSS MEGGGGQKKN SVRHKLVSLT LKKKSKITEE VTRRLTDGDY
SLQGNSMLED RPTSNLEKLH FIIGNGILRP ALRDEIYCQI CKQLTQNPSK SSHARGWILL
SLCAGCFAPS EKFVKYLRAF MINGPPGYAP YCEERLMRTF VNLTRTQPPS WLELQATKSK
KPIMLPVTFM DGTTKTLLTD SATTASELCN ALADKINLRD RFGFSLYIAL FDKVSSLGSG
SDHVMDAVSQ CEQYAKEQGA QERNAPWRLF FRKEIFTPWH NPSEDSVATN LIYQQTVRGV
KFGEYRCERE EDLAELASQQ YYVDYGVEVL PERLLNLIPS YIPDREISST KTTEKWAQLI
TSAHKKGVYT QKRLDPQRVK EDVVDFARFK WPLLFSRFYE AFKFSGPSLP KNDVIVAVNW
TGVYFVDEQE QVLLELSFPE ITAVSSSRSI TITWILFSLG GKLQGQSFSL ATIKGDEYTF
TSNNAEDIRD LVVTFLEGLR RRSKYVVALL DCPNPAGGED STFLSFSKGD LIILDEHCGE
QVMTSGWAHG VNDRTKHRGD FPYDIVVGDQ RRESISLSQL ALAQSEGKVK PYTLEEFSYD
YFRPPPKSTL SRVMITKGRV KERLWCCTRE PLKQPLLKKV LAHEELSQEA QLYMGDYPSK
RTRSVNELTD QIFEGSLKAE PLKDEIYCQI LKQLTENHIK FSEEKGWELL WLCTGLFPPS
NVLLPHVQKF LQAKKHYPLA PDCMQRLQKA LRNGSRKYPP HLVEVEAIQH KTTQIFHKVY
FPDDTDEAFE VESSTKAKDF CLNIAGRLLL KSSEGFSLFV KITDKVISVP EGDFFFDFVR
HLTDWIKKAR PAKDGVVPSL IYQVFFMKKL WTNTIPGKDS MADSIFHYYQ ELPKYLRGYH
KCSQEEVFQL AALIYRVKFE EDKSQFPNIP KMLKELIPQD QIRHLSPDDW KRSIVALFNK
QAGKTREEAK LSFLKVIFKW PTFGSAFFEV KQTTDPNFPE TLLIAINKHG VSLIDPKSKD
VLTTHPFTKI SNWSSGNTYF HITIGNLVRG TKLLCETSLG YKMDDLLTSY ISQMLTTMTR
QRGSRGNIK
//