ID   A0A3P8YP25_ESOLU        Unreviewed;       650 AA.
AC   A0A3P8YP25;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Elongation factor for RNA polymerase II {ECO:0000313|Ensembl:ENSELUP00000018315.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018315.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000018315.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000018315.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ELL/occludin family.
CC       {ECO:0000256|ARBA:ARBA00009171, ECO:0000256|PROSITE-ProRule:PRU01324}.
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DR   RefSeq; XP_010870007.1; XM_010871705.3.
DR   AlphaFoldDB; A0A3P8YP25; -.
DR   STRING; 8010.ENSELUP00000018315; -.
DR   Ensembl; ENSELUT00000040532.2; ENSELUP00000018315.1; ENSELUG00000017856.2.
DR   GeneID; 105011571; -.
DR   KEGG; els:105011571; -.
DR   GeneTree; ENSGT00940000155914; -.
DR   InParanoid; A0A3P8YP25; -.
DR   OMA; DECVPEP; -.
DR   OrthoDB; 2910197at2759; -.
DR   Proteomes; UP000265140; LG08.
DR   Bgee; ENSELUG00000017856; Expressed in ovary and 14 other cell types or tissues.
DR   GO; GO:0008023; C:transcription elongation factor complex; IEA:InterPro.
DR   GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 6.10.140.340; -; 1.
DR   Gene3D; 1.10.10.2670; E3 ubiquitin-protein ligase; 1.
DR   InterPro; IPR042065; E3_ELL-like.
DR   InterPro; IPR031176; ELL/occludin.
DR   InterPro; IPR019464; ELL_N.
DR   InterPro; IPR010844; Occludin_ELL.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23288; OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR   PANTHER; PTHR23288:SF9; RNA POLYMERASE II ELONGATION FACTOR ELL; 1.
DR   Pfam; PF10390; ELL; 1.
DR   Pfam; PF07303; Occludin_ELL; 1.
DR   SUPFAM; SSF144292; occludin/ELL-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51980; OCEL; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          536..646
FT                   /note="OCEL"
FT                   /evidence="ECO:0000259|PROSITE:PS51980"
FT   REGION          285..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  72087 MW;  3EC2CE905DE62574 CRC64;
     MAALKEEQCY GLSCGRVSNG SNVSVFHVKL TDSALRAFEG YQSSKGLSSQ PLIRFTGNQG
     KIVIPRSENP NELRTFTFYL SNVGRDNPQG SFDCIQQYIT SEGSIQLDCL GGIQDKITVC
     ATDDSYQKAR QSMAQAEEET RSRGAIVIKP GGRYVGKKVQ IRKPAPGLSD IAPSRRTSRP
     VIISSSTVKK STAQQRPLRE RLTHLLALKP YRKPELILRL QKDGLLPYDK DSLDSLLQQV
     ANLNGRDNTF TLKDSLFKDI QKDWPGYSEG DQQLLKRILV RKMCQGQSQT PSTTTSVAPP
     PPVELPLSMS PPKEVASSSP SQKRPAADFI DPLANKKPRI SHLANKATGP INGKLSSSNG
     KEASGAVVSA VGDGVAASSQ LPLLDIPRPF DPLSDVSNDS SHNGRDCEGQ EAAVAERLSQ
     PSVFSGPATL SVPGLGPSSP RHTGLEGPQG KSTSPSLHGK SKKKSKKHKD KDKSKERERE
     RERKGTEERV PEPRKTFEIC TSSSENLKGS SIPHRSTDRN GMCNNISVPS SSTEMADYLS
     KYTVIGSSEQ RQTYKNDFNT EYSEYRDLHA RIEGITRQFT VLDSELKQLQ QGTEKYKTIH
     NQIFQEYRKI KKTNPNYSQE KNRCEYLHNK LAHIKKLIAE YDQQQLQNWH
//