ID   A0A3P8YPG3_ESOLU        Unreviewed;       786 AA.
AC   A0A3P8YPG3;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN   Name=CUL5 {ECO:0000313|Ensembl:ENSELUP00000018455.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018455.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000018455.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000018455.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; A0A3P8YPG3; -.
DR   STRING; 8010.ENSELUP00000018455; -.
DR   Ensembl; ENSELUT00000028359.2; ENSELUP00000018455.2; ENSELUG00000018014.2.
DR   GeneTree; ENSGT00940000156648; -.
DR   OrthoDB; 5474206at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000265140; LG07.
DR   Bgee; ENSELUG00000018014; Expressed in ovary and 15 other cell types or tissues.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          401..636
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   786 AA;  91590 MW;  5AFE6C21B45AE0CC CRC64;
     WPMSGLIHRS LQFEDKWELM RPIVLKLLRQ ESVTKQQWFD LFSDVHAVCL WDDKGPAKIH
     QALKEDILDF IKQAQARVLS HQDDTALLKA YIVEWRKFFT QCDILPKPFC QLEITLMGKQ
     GSNKKSNMED SIVRKLMLDT WNESIFSNIK NRLQDSAMKL VHAERLGEAF DSQLVIGVRE
     SYVNLCSNPD DKLQIYRDNF EKAYMDSTER FYRTQAPSYL QQNGVQNYMK YADAKLREEE
     KRALRYLETR CECNSVQALM ECCVNALVTS FKETILAECP GMIKRNETEK LNLMFSLMDK
     VPSGIEPMLK DLEDHIMSAG LADMVASAET ITSDSEKYVE QLLTLFNRFS KLVKDAFQDD
     PRFLTARDKA YKAVVNDATI FKLELPLKQK GVGLKTQPES KCPELLANYC DMLLRKTPLS
     KKLTSEEIEA KLKEVLLVLK YVQNKDVFMR YHKAHLTRRL ILDISADSEI EENMVEWLRE
     VGMPADYVNK LARMFQDIKV SEDLNQNFKE CHKHNKLALS ADSVNIKILN AGAWSRSSEK
     VFVSLPTELE DLIPEVEDFY KKNHSGRKLH WHHLMSNGII TFKNEVGQYD LEVTTFQLAV
     LFAWNQRPRE RISFENLKLA TELPDAELRR TLWSLVAFPK LKRQVLSYDP VVSSPKDFAE
     GTLFYVNQEF SLIKNSKVQK RGKINLIGRL QLTTERMREE ENEGIKGLLI VGIHLRSVFS
     FKEAIIQIMK MRKRLTNAQL QTELVEILKN MFLPQKKMIK EQMEWLIDHK YIKRDETDLN
     TFLYMA
//