ID A0A3P8YPP0_ESOLU Unreviewed; 550 AA.
AC A0A3P8YPP0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Leucine rich repeat LGI family member 3 {ECO:0000313|Ensembl:ENSELUP00000018530.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018530.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018530.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018530.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010874286.1; XM_010875984.3.
DR AlphaFoldDB; A0A3P8YPP0; -.
DR STRING; 8010.ENSELUP00000018530; -.
DR Ensembl; ENSELUT00000028428.2; ENSELUP00000018530.1; ENSELUG00000032426.1.
DR GeneID; 105014026; -.
DR KEGG; els:105014026; -.
DR GeneTree; ENSGT00940000160296; -.
DR InParanoid; A0A3P8YPP0; -.
DR OMA; EGDWFFA; -.
DR OrthoDB; 4083661at2759; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000032426; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24367:SF10; LEUCINE-RICH REPEAT LGI FAMILY MEMBER 3; 1.
DR PANTHER; PTHR24367; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF03736; EPTP; 7.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50912; EAR; 7.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..550
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017940047"
FT DOMAIN 171..220
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 550 AA; 63484 MW; 5EA9EFA9F6B09F7B CRC64;
MLDAGSRKVT GWLRLLANLC LLLCLVGEMR AKRVTKIPRC PTTCSCTKDS AFCVDTKAIP
KTFPPGIISL TMVNAAFTTI PEGAFSHLHL LQFLLLNSNT FTVVADDAFA GLSHLQYLFV
ENNDIHALSK HTFRGLKSLT HLSLSNNNLQ LLPREIFKHL DTLTDLDLRG NSFRCDCKIK
WLIDWMEQTN TSVPAIYCAS PFEFQGRRIH DLTPRDFNCI SADFAVYETF PFQSVSVESY
EFNGDQFVAF AQPDSGFCTL YMWNHVEMVF RRYHNITSRS AVYCKPVVIN NTLYMVVAQL
FGGSHIYKWE EDPQRFVKIQ DIDTTRVRKP NFVETFQLDD EWYFAVADSS KAGSTSIYRW
NSNGFYSHQS LHPWHRDTHV EFLDVEGKQR LILSSASQPP MVYQWNRSLR QFAFYSQITE
TADVQMVKHF WIRKVLYLCL TRFIGDSKIL RWEGQRYVEI QTLPSRGSMV VYPFTVGPRQ
YLLLGSDFSF SQVYLWDDLT HRFQPFQELN MRAPRAFSLV SVDNKDILLA ASFKGNTLAY
QHLIVDLSAR
//
