ID A0A3P8YQ21_ESOLU Unreviewed; 993 AA.
AC A0A3P8YQ21;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018650.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018650.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018650.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR RefSeq; XP_010894482.1; XM_010896180.2.
DR RefSeq; XP_019909471.1; XM_020053912.1.
DR AlphaFoldDB; A0A3P8YQ21; -.
DR STRING; 8010.ENSELUP00000018650; -.
DR Ensembl; ENSELUT00000040662.2; ENSELUP00000018650.1; ENSELUG00000000744.2.
DR GeneTree; ENSGT00940000159190; -.
DR InParanoid; A0A3P8YQ21; -.
DR OMA; AMHHLLC; -.
DR OrthoDB; 1065060at2759; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000000744; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 6.10.250.1040; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR018410; Na/H_exchanger_3/5.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF56; SODIUM_HYDROGEN EXCHANGER 5; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01087; NAHEXCHNGR3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..993
FT /note="Sodium/hydrogen exchanger"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018174388"
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..515
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 705..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..726
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..960
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 993 AA; 109802 MW; FBD34A2F2B0D743F CRC64;
MMLLSSVSVL LLLSVAGEAA ADLSVPEASL HPKLGLRDVG GPGPSLPASP TASRLQVQRQ
NEYASPGIAL ARSAEEPSAT TEEGSESHHH GGGFQMVQWE WSYVQTPYII AIWILVASVA
KILFHFSQRF TTVVPESCML ILLGLVLGGI VLLASKKQLY QLEPGLFFLF LLPTIVGDAG
YFMPARLFFD NLGAILLYAV VGTLWNAFCT GFCLYGAKMV GVIDEKVQAG LMEFLLFGAL
ISAVDPVAVL AVFEEVHVNE TLFIIVFGES LLNDAVTVVL YKVYMSFVEV GSENVQTADY
FKGVASFLIV SIGGTLVGLI FAALLAFITR FTKKVRIIEP LFVFLMVYLA YLTAELFSLS
AILSMTFCGI GCNKYVEANI SQKSRTTVKY TMKTLASIAE TIIFIFLGIS AVDKSKWAWD
TGLISCTLIF IFVFRALGVV MQTWVLNWFR LVPLDKIDQV VMSYGGLRGA VAFALVVLLD
ADQVPAKDYF VATTIIVVFF TVMFQGLTIK PLVNWLKVPR ATNRKPTINE EIHERAFDHC
LTAVEDIAGL NGYHHWRDKW EQFDKNYLSK LLLRKSVYRK SELWEAYQKI NIRDAISVID
QGGNVLTSAR FSLPSMASRT SFPEVTNVTN YLRENGSGVC LDLQVIDNVS GAKVEEESET
HHFLAGNLYK PRRRYQSHYS RHFMTPGDHE RQDREIFQRN MRSRMETFKT TRHKRHSHKK
DRSQKKRRGS DVKEQDLNDK PRRNVSWQDK DPVVVPVDSE EEKGEHSEPE KEEDVGITFV
ARKVPETPKE RPKSVPSALE VCQSPSAAPP SPTCGERNLP WKGGIGTLPV CVSMEATKII
PIDLQQAWNQ SISSLESLAS PSIPPEPLHP RVSALSRLGG PRPVSYSGSG VSGPGYPGAG
GGASRSIVAQ GIARFEFPRG EEKEEEERAL SDKEQEMQPL MSSSVRPSGP SPPPPPSLGL
GRRRNPCVYL RSLVTSPPSG TEPPARSRGP TQL
//
