ID   A0A3P8YQ92_ESOLU        Unreviewed;       824 AA.
AC   A0A3P8YQ92;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Semaphorin 4B {ECO:0000313|Ensembl:ENSELUP00000018051.2};
GN   Name=SEMA4B {ECO:0000313|Ensembl:ENSELUP00000018051.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018051.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000018051.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000018051.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   AlphaFoldDB; A0A3P8YQ92; -.
DR   Ensembl; ENSELUT00000027807.2; ENSELUP00000018051.2; ENSELUG00000017664.2.
DR   GeneTree; ENSGT00940000154870; -.
DR   Proteomes; UP000265140; LG17.
DR   Bgee; ENSELUG00000017664; Expressed in spleen and 15 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF14; SEMAPHORIN-4B; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..824
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5028109018"
FT   TRANSMEM        693..717
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..507
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   REGION          728..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  92117 MW;  519051D7D469C435 CRC64;
     MAGLCLLAAA LLLVEWVGAV TASEDDVIPR ISFPYNALER PAKRFSADGV SNYTSLLLRL
     DDDTLYVGAR ESLFALRLQD ISSTTLSRNL TWETPTRKRE ECSFKGKSFQ TDCVNYIKIL
     LPLNSTHLYV CGTYAFSPIC AYINTSTFSL ERDERGQIIL EDGRSRCPFN PDYQSTAIIV
     DGELYAGTVS NFQGNEPVIY RSLGGGPSLK TENSLNWLQD PSFVGSAHLQ ESQPLGNPVG
     DDDKVYFFFS ETGKEFDFFD NTIVSRIARV CKGDKGGERV LQKKWTTFLK AQLLCSLPDD
     GFPFNIIQDM FVLTPDGEAW ENTLFYGVFT SQWYTGASSS SAVCAFTMAQ VERAFSGRYR
     EVNRETQQWY TYNHPVPEPR PGCVTNTARD QGIQSSLHMP DKVLNFVKDH FLMDHVIRSS
     PLLLKRSVRY TQIAVHKVQG MERAYDVLFI GTDDGKLHKA INSNDKMHII EEMILFSEPQ
     PIQHMELDAR RGLLFISSYS GVVEVPVANC SNYQGCGECV LSRDPYCAWT GRQCLDVRLA
     PPDSHWQQDV EEADTSAICN KTVPIPRVSQ CQKITLPANS FRVLPCPLRS NLAKRRWAYA
     PSASPFLLPT PDGGLVVVAQ PDSCHTYECW SHEEGFTQLL ANYCVRAEPG PPQLESTTLI
     GHSRTPQVNQ DQVESIIILP EEAPSTQLNS KTYWAELVGV CGLLAVCLLL FSLLLLYRGR
     GSMKALLKDR DQRPSMQQKK ARLAGGKPAE SLPLNSNTIP VSTSDHKGYQ TLNDNYISTT
     PTLTTFSEAS ERRPLNLRES HVEISDTCPR PRVRLGSEIK DSIV
//