ID A0A3P8YQH5_ESOLU Unreviewed; 516 AA.
AC A0A3P8YQH5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=UDP-sugar transporter protein SLC35A5 {ECO:0000256|ARBA:ARBA00040377};
DE AltName: Full=Solute carrier family 35 member A5 {ECO:0000256|ARBA:ARBA00041937};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018805.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018805.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018805.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable UDP-sugar:UMP transmembrane antiporter involved in
CC UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-
CC glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport
CC from the cytosol to the lumen of the Golgi.
CC {ECO:0000256|ARBA:ARBA00037779}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:67138;
CC Evidence={ECO:0000256|ARBA:ARBA00036186};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695,
CC ChEBI:CHEBI:57705, ChEBI:CHEBI:57865;
CC Evidence={ECO:0000256|ARBA:ARBA00036522};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-
CC glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:58052; Evidence={ECO:0000256|ARBA:ARBA00036726};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR AlphaFoldDB; A0A3P8YQH5; -.
DR Ensembl; ENSELUT00000029015.2; ENSELUP00000018805.2; ENSELUG00000018253.2.
DR GeneTree; ENSGT00950000182827; -.
DR Proteomes; UP000265140; LG20.
DR Bgee; ENSELUG00000018253; Expressed in stomach and 14 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR NCBIfam; TIGR00803; nst; 1.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF90; UDP-SUGAR TRANSPORTER PROTEIN SLC35A5-RELATED; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 496..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 57784 MW; 7ED6D189B317586B CRC64;
MNFISFDWFP NVYMQNHRTS KSFLRQSNIM SLLRRATTVS CPLRLRASRS TRKQTRSRNT
SGNAIRGLSE VVEEEPSVCV VVLDTAPSMA CCQQSPGLCR HLSTYTLALG LGFVTLGTSR
VVLLKMSANA HNKYDFLPAS VNLLAEGLKL VFCLAMSLRV MVREGRSCRE LRCSSVLSFL
TFMKWSVPAF LYFLDNLIIF YVMTYLQPAM AVLFSNFVIL TTAILFRLVL KRRLSWVQWA
SLLILFLSIV SLTQGSGGSH KVIAMPGLRP RPFSRPSNSC LLYTQLKEQQ RIDSNSSTWG
SGLPGQAEEW RGKMMGSTHS LGVGHILLVL QCFISSMANI YNEKIIKEGD QLQESVFIQN
SRLYLFGILF NGLLLGVGSE TRGVVVHCGV LYGHNVYSLA LVVVTAALGL SVAFILKFRD
NMFHVLTGQI TTVLVTTLSL FLFQFRPSLD FFLQVPVVLL AIFVYNASRP MDPEYVMQRA
KLRVINGEVL HRSRGDGEEL ERLTKTSTDS ESEVSI
//
