ID A0A3P8YQL3_ESOLU Unreviewed; 659 AA.
AC A0A3P8YQL3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=CBFA2/RUNX1 partner transcriptional co-repressor 3 {ECO:0000313|Ensembl:ENSELUP00000018884.1};
GN Name=CBFA2T3 {ECO:0000313|Ensembl:ENSELUP00000018884.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018884.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018884.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018884.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8YQL3; -.
DR Ensembl; ENSELUT00000028867.2; ENSELUP00000018884.1; ENSELUG00000000775.2.
DR GeneTree; ENSGT00950000183176; -.
DR Proteomes; UP000265140; LG02.
DR Bgee; ENSELUG00000000775; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 6.10.250.230; -; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR013289; CBFA2T1/2/3.
DR InterPro; IPR014896; NHR2.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR10379; MTG8 ETO EIGHT TWENTY ONE PROTEIN; 1.
DR PANTHER; PTHR10379:SF6; PROTEIN CBFA2T3; 1.
DR Pfam; PF08788; NHR2; 1.
DR Pfam; PF07531; TAFH; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PRINTS; PR01875; ETOFAMILY.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 112..207
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT DOMAIN 545..581
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 472..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 49..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..297
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..425
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 71991 MW; ECDA6995E96175F1 CRC64;
MKTGSAEEPV ILGNTEQKVG TMPDSPADVK TQPRSTPPTM PPPPPAVSQA ANRNASFTPT
TSKSMLNGSS HSSHSPTSLN GAPSTPNGFS NGPAMSSTAS LSNQQLPPAC GARQLCKLKR
FLTTLQQFGN DISPEIGERV RSLVLGLVNS TLTIEEFHSK LQEATNFPLR PFVIPFLKAN
LPLLQRELLH CARMAKQTPA QYLAQHEQLL LDANASSPLD SSEIMMEINE HGKRRTPDRT
KDSDRDGHHP EHLAKRPCTI SPSQRFSPST GLPAHPPPNG LPTHPPNGLP HPNPPAPQHY
RLEDMALAHH YRDAYRHTAE HREARDRHRQ TAVHGARQEE VIDHRLTDRE WAEEWKHLDN
LLNCIMDMVE KTRRSLTVLR RCQEADREEM NHWIRRYSDV EDMKKGGSNG QPRPPPPPPP
PHNSSSNTPN NVETLQSIEI HRDFLHRPAS GYLPEEIWRK AGTTSIPLSP ALKQLQNKQE
EAVNEVKRQA MSELQKAVSD AERKAHEMIS AERSKMERAL AEARKQASED ALTVINQQED
SSESCWNCGR KASETCSGCN TARYCGSFCQ HKDWEKHHHV CGQGLQGLPG GSSVPLGTPS
SGAPPTHSES SPPGPLSQAG GGGGGGSVSG SPKEASSSSS SASRSTTPAT PALLDATSR
//
