ID A0A3P8YQM6_ESOLU Unreviewed; 948 AA.
AC A0A3P8YQM6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|Ensembl:ENSELUP00000018191.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000018191.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000018191.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000018191.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3P8YQM6; -.
DR Ensembl; ENSELUT00000028029.2; ENSELUP00000018191.2; ENSELUG00000017795.2.
DR GeneTree; ENSGT00940000155129; -.
DR Proteomes; UP000265140; LG09.
DR Bgee; ENSELUG00000017795; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878:SF69; SODIUM CALCIUM EXCHANGER 1H; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..948
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027968697"
FT TRANSMEM 71..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 386..486
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 517..617
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 948 AA; 105261 MW; 651452B464066193 CRC64;
ILKFTVFFVF FSSEITFIAA GSSHPSLGKN SSIINETNKK CDSAGTECKV GVILPIWLPE
NPSFGDKLAR ATVYFVALFY MFLGVSIIAD RFMASIEVIT SQEREITIKK PNGEIITTTV
RIWNETVSNL TLMALGSSAP EILLSVVEVC GHNFDAGDLG PNTIVGSAAF NMFVIIGLCV
SVIPDGEHRK VKHLRVFFVT ATWSIFAYTW LYLILAVISP GIVEVWEGLV TLFFFPLCVG
MAYIADRRLL VYKYMYKRYR AGKRGGVIIE TEGEVQLSSK MDIEMDGKIL NSEGVLDGAI
GFDEKELDEE DARREMARIL KELKQKHPEK ETEQLIELAN YQVLTQQQKS RAFYRCQATR
IMTGAGNVLK KHAADHARKA VGLHEIHSEA LENDFPSKIF FDPGTYQCLE NCGTVALNVV
RLGGDLTNTV SVEYRTEDGT ANAGSDYQFT EGVVVFKPGE TEKEIRIDII DDDIFEADEH
FLVHLSNVKV ISEGTGYRQP GFNHTDSLAG LGLPCSATVT IFDDDHAGIF TFEEPVMTVS
ESIGQMEVKV LRTSGARGLV VVPYKTIEGT AKGGGEDFED TYGALEFQND EIFKTIQINI
IDDEEYEKNK NFFLEMGEPR MVEMSERKGG FMKTGRDVYR KVQSRDNPVP STIISIAEER
DEEALSKKEE AERLIAEMGR PTLGEHVKLE VIIEESYEFK NTVDKLIKKT NLALLIGTNS
WRQQFMEAIT VSSGDSDDEC GEEKLPSCFD YIMHFLTIFW KLLFAFVPPT DYWNGWACFV
VSITMIGLLT AFIGDLASHF GCTVGLKDSV TAVVFVALGT SVPDTFASKV AAIQDQYADA
SIGNVTGSNA VNVFLGIGVA WSIAAIYHNS KGNDFRVDPG TLAFSVTLFT IFAFVCVAVL
MYRRRPEIGG ELGGPRGPKI ATTCLFFSLW LMYIIFSSLE AYCHIKGF
//
