ID A0A3P8YR67_ESOLU Unreviewed; 4601 AA.
AC A0A3P8YR67;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Plectin {ECO:0000313|Ensembl:ENSELUP00000019060.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000019060.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000019060.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000019060.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSELUT00000040841.2; ENSELUP00000019060.2; ENSELUG00000018494.2.
DR GeneTree; ENSGT00940000162855; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000018494; Expressed in nose and 14 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd06503; ATP-synt_Fo_b; 1.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 6.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF32; PLECTIN ISOFORM X1; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 15.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 30.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 7.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 58..161
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 174..279
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 821..878
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1516..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1668..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4268..4288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4500..4548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 774..804
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1043..1070
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1156..1204
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1258..1285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1354..1448
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2120..2163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2172..2188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4268..4286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4601 AA; 525831 MW; 8C06374E8A01C567 CRC64;
VVGAMADVTP PASVVFSPYG VLQEEIIYGR AIFINEMSCG EVGSHLYSRM CCADERDRVQ
KKTFTKWVNK HLMKAQRHIT DLYEDLRDGH NLISLLEVLS GETLPREKGR MRFHKLQNVQ
IALDFLKHRQ VKLVNIRNDD IADGNPKLTL GLIWTIILHF QISDIQVNGQ SDNMTAKEKL
LLWSQRMVEG YHGMRCDNFT TSWRDGKLFN AIIHKHRPSL IDMSKVYRQT HVENLEQAFS
VAERELGVTR LLDPEDVDVP HPDEKSIITY VSSLYDVMPR VPDVQDGVKA NELELRWQEY
YELVTLLLQW IRHHIIVFEE RKFPTSYEEI EVLWRQFLKF KETELPAKEA DKNRSKQIYM
SFEGAVQAGH VKVPPGYHPF DVEKEWGRLH VAILERERLL RTEFERLERL QRIVSKVQME
SGVCEEQLNQ AEGLLQMDIR LLSSGKPGIH TAEIETDLDK AESMIRYLFN DVQILKDGRH
LQAEQMYRRV YRLHERLVNL RSEYNLRLKS GVTHAQIPMT QTLQQAAVGV CPELDKVTLR
YIQDLLVWVE ENQRRVDQGE WGSDLPNVES QLGSHRGLYQ SVEEFHAKID RAKADENQLS
PVSKGAYRDY LSKLDQQYGK LLSSAKARLR SLDGLHAFVT AATKELIWLN EKEEDEVNYD
WSERNTNMTA KKDNYSGLMK ELEQREKRVN SVQVQGDKLL KEGHPAKKTI EAFSAALQTQ
WSWILQLCCC IESHLKENTA YFQFFSDVNE AKEKIKKMQE TMKKKYTCDR NITVTRLEDL
LQDAADEKEQ LKDFKAHLDG LNRRAKTIVQ LKPRNPATPV KGIVPVQAVC DFKQMEITVH
RGDECKLLDN SQPYQWKVQN PKGCEATVPS ICFLVPPTNK EAVSSVSGLD SSHQDLLVLW
RRLHIDMKSL MSWQYLMRNI NLINTWNITM FKTLSVEEYK LALRNLELHY QNFLRDSQDS
QLFGADDRMQ VESDYNKASQ HYEELLHSVE KGEQDESECR IYLTKIKDLR LKLEGCETHT
ITRLRQPVTN EPLKACTQRT AEQKKVQTEL EALKNNLADV AEKTEEVLAS PQQFSSAPVL
RSELDVTMKK MEHVYSLSSV YLDKLKTIDI VINSIKGAEV TVKKYESRLR DVTKMPTDEN
EVENHLTQLK TMCGEVEGEQ KMFDTLQEEL RQATAVNEQM TRVHSERDNE LEHYREIVAR
LEERWQAVFI QIDLRERELD FVGRQMHSYR ESYNWLIRWL GDAKQRQEKI QAVPIGNSKA
LKQQLAQEKK LLEEIEKNKD MVEECQKHAR AYIDAVKDYE LQVVTYKALV EPMASPLKKT
KMECASDDII QEYVTLRTCY SELMTLTSQY IKFITETQRR LEDEEKATEI LKEEERKKLA
EMQAELDKQR QLAEAHAKAI AKAEQEAQEL KLKMQEEVSR REVVKVDSEK QKYNIQQELQ
ELKSLSEQEI QTKSKQVEEA LYSRTKIEEE IHIIRIQLET TMKQKAAAEA ELQQLRDMAA
EAERLRKVAQ EEAEKLRKQV NKESQKKRNA EEELKRKAEA EQEAARQKQK ALDELQKFKT
QVEEAERRMK QAEEEKQRQV MVAEEVAQKS ATAELQTKRI SLNEKAVKLE ASLKQEQGTV
IHLQEEAEHL KKQQEEASKA REEAEKELEK WRQKANEALR LRLQAEEEAL KKSQAQEEAE
KQKEEAERDA KKRAKAEEAA LKQRDMAEKE LEKQRKLAEV TAQQKLSAEQ ELIRLKADFD
HGKQQRSLLD EELQRLKNEA NAALTQRKQL EDELARVKSE MEVLLQMKSK AEKEAMSTTE
KSKHLLESEA LKMRQLAEEA TKLRIIAEEA KKQRQVAEDE AARQRGEAEK ILKEKLSAIN
EATCLKTEAE IALKDKEAEN ERLRRKAEDE AYQRKVLEDQ AKQHKQDIDE KITQLKKTSE
SEMERQKKIV EETLKQRRVV EEEISILKLN FEKATTDKLD LELELNKLKG IADEAEKNKV
KAEEEAEKLR KLALEEENKR KQAEEKVKKI TAAEEEARQQ RQAAQKDVER LKKIAADAKK
QKEDADKETE KQICLAKEAA EKCSAAEKKA HDVLTKQKED SLSQGKFKEE FDKAKKLANE
AEKAIVKAEK EAALLRQKAE DAEKLKKAAE AESAKQAKAQ EDAERLRKEA EQEAAKRAEA
ESAALKQKQQ ADAEMAKQKK LAEKTVKQKT QVEQELTKVK LQLDETDRQK SVLDEELQRH
KDEVSNALKQ KAQVEEELFK VKVQMEELIK LKLKIEQENQ YLMSKDKDNT KKLLEEEAEN
MKKLAEDAAR LSVEAQEAAR ERMIAESELA EQRALAEKML KEKMQAIQEA TKLKAEAEKL
QKQKEKAQEQ AQQLLEDKQQ MQQRLEEEIE CFQKSLEAER KRQREATAEA EKLKLRVTQL
SEAHSKSEEE AKKFKKQAEE IKICLQQKEQ QAAEKVIVEK LEVQRLQSSK ESDDLRKAIV
NLEKEKEKLQ KEAADLQNKS KEMATAQQEQ MKQEKNIIEQ TFLTEKKMLL EKERLIEEEK
KKLEKQFEDE IMKAKALKDE QDYQKKLMEQ EKKLLQAAMD AAVKKQKDAE EEMRNKLNEI
KDLEKKRLEQ EKLLNEENKK LREKLEHLST PRKSTTSLTK EMEIQTDDVP EDQLIAMTMV
GTTKKAFNGS AEQDSAKKEE SPFTFDGIRE KVTANRLHDI GILNKKDFDR LKKGKTTVQD
MSKTEKMKTC LKGNNCVGGV LTPTQETMSV YQAMKEKKIS SAAGTMILEA QAACGYIIDP
VKNRMLSVDE AVKEELIGPE LHNKMLSAEK AVTGYKDPYT GDKISLFEAM RKSLIEQDRA
IRLLDAQIAT GGIIDPVNSH RVPLQTAYKQ GQLDAEMNKT LLKPTDDSKL FIDPSTQEML
TYQHLLDRCI PDAETGILLL PITENASRSE KTYTSDETKD VLTKATISVP FGRFQGKAVT
IWEIINSEYF TGTQRKDLIR QYKTGKITVE KIIRIVISVV EDKEKSHEIV FDGLRNPVTA
GELLESKIIN KDLFNILHNG KTTVKEISEM EPVKKALGGT YSIAGVIIES TNEKITFYQA
VKNKMLTPET GLSLLEAQAG TGFVIDPVNN QKLTVDEAVK SCLVGPELHE KLLSAERAVN
GYKDPYTGKT VSLFEAMKKD LIKNDQGIRL LEAQLATGGI IDPVRSYHIP HELACKRGYF
DDEMNKILCD NTDVTKVFFD PNMWENASYN QLMKKCVTDQ ETGFPLLQLS EKAIQNSKEM
QKSKDEQQYT EDQSKDALNQ TTMELQFGPF KGRKVTIWEI INSEYITETQ RIELIRQYRT
GTVTIERMIT IMVTMINEKE TKKLEKEQPS FEGLRAAVTS SSLFESKIID KDTYDQLQQG
KKKPKEISDI DPVRTYLQGA GGQIAGIFMG DSKEKVSIYQ AMKKKILRQK TGLTLLEAQA
ATGFIIDPIK NQRYTVDDAV KAGVVGPEVH EKLLSAEKAV IGYRDPYTGN KISLFQAMKK
ELVLREHAIP LLEAQVATGG IIDPINSHRV PNDVAFQRGY FSKQMAKSFA DPSGDVKAFV
DPNTNESSTY KQLQDKCIKD PDTGFCFLTL STAEAQSPVE QSYVYNEQQA QTDLANTQVD
IPHPNYSGKI MNLWDVMRSN MLPEEEKLRL LEQYRRGQIT KERMIIIVIE IIEQREILKA
EQSMSCDMIR RRVNIEELYS SRILDLETYN MLKQEKKTIR EVMEMPSVKQ YLFGTGSIAG
ILSDALSKVS IYQALKRGLI KPDFGISLLE AQAATGFIID PVKEELLTVD EAVRKGLVGP
EIHDKLLSAE RAVTGYKDPY SGKSISLFQA MKKDLIPEDY ALRLLEAQVS TGGIIDPEYY
FHLPIDVAMQ RGYINKETHD RITNSNSDVQ GYVDPTSDEK QTYAQLLKRC KVDKESGLRL
LSLADRRLLF KGLRKQITLD ELLRSQIINQ KTYNDLIDGL ISVEEVSREV KKYLEGASCI
AGVYVESSKE RLSIYQAMKK NMIRPGTAFE LLEAQAATGY VIDPIKNLKL NVSEAVKMGV
VGPEFKDKLI SAERAVTGYR DPYSGMTMSL FQAMKKGLIL KEHGIRLLEA QIATGGIIDP
EESHRLPVEM AYTRGLFDEE MNCILTDPAD DTKGFFDPNT EENLTYLQLM ERCMIDPETG
LALLLLKEKK RERKTSSKSS VRKRRVVIVD PETGKEMSVY EAYRKGLIDQ QTYMELAEQE
CEWEEITISS SDGVVKSMII DRRSGRQYDI DDAITKGLID QSALDQYRAG TLSITEFADM
LSGNMSGTRS RSSSFGSTSS YSSSPAPAIK PPAVVWNDPT EETGPVAGIL DTDTLEKVSV
TEAMHRNLVD NITGQRLLEA QACTGGIIDP NTGEKFSVAE AMNKGLVDKI MVDRINLAQK
AFNGFEDPRT KTKMSAAQAL KKGWLYYEAG QRFLEVQYLT GGLIEPDVTG RVPLDVAVNK
GTLDARTAQK LRDVSGYSKY LTCPKTKLKI SYKDALERSM IEEGSGLRLL EASSQSTKGL
YSPYSVSGSG SASGSRPDSR TGSRSGSRRG SFDATGSSFS PSFSSSSFSS TSYGRRYDAG
SHSGLHIKEL ALALVSLAVT RNCSLDDGIF TTIQLSRSAV A
//
