ID A0A3P8YT73_ESOLU Unreviewed; 986 AA.
AC A0A3P8YT73;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Semaphorin 6A {ECO:0000313|Ensembl:ENSELUP00000019771.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000019771.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000019771.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000019771.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A3P8YT73; -.
DR STRING; 8010.ENSELUP00000019771; -.
DR Ensembl; ENSELUT00000029987.2; ENSELUP00000019771.2; ENSELUG00000019137.2.
DR GeneTree; ENSGT00940000156565; -.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000019137; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF12; SEMAPHORIN-6A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..986
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027828648"
FT TRANSMEM 633..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..511
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 346..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 109701 MW; 1E688A132A1DDA44 CRC64;
MRSEALLLYF TLLQIAGAGF PEDSEPISIS HGNYTRQYPA FVGHKPGRNN TQRHKLDIQL
IMIMNRTLYI AARDHIYTVD TDTPYSEEIY FSKKLTWKSR QADVDTCRMK GKHKDECHNF
IKVLLQQNDD TLFVCGTNAF NPSCRTYKMD TLDAVGEEIS GMARCPYDSK HSNVALFADG
KLYSATVTDF LAIDAVIYRS LGDSPTLRTV KHDSKCLKEP YFVQAVDYGD FIYFFYREIA
MEYNTMGKVV FPRVARVCKN DRGGSQRVLE KQWTSFLKTR LNCSIPGDSH FYFNILQAVT
DVIHINGRDV VMATFSTPYN SIPGSAVCAY DMAEVANAFT GRFKEQKSPD STWTPVPEEK
VPKPRPGCCA GTPSLERYKV SNEFPDDTLN FIKQHPLMDE AVPSIANRPW FLKTMVRYRL
TRIAVDNIAG PYRNHTVVFL GSEKGIILKF LAKMNSGFLN DSLFLEELNV YNPEKCSIDG
VDDKRIVSMQ IDSQGHSLFV AFTSCVVRVP LSRCERHGKC KKSCIASRDP YCGWVSEGAC
KQVALDAKWR FEQDVEHGNT DGLGDCQSHS TLPFPTTAHP PAGGPLGRGG MVEQADPPEP
SDKRNPYMAV PSQTQQDANG VIRESYQKGR DQLVPVTLLA IAVILAFAMG AVFSGVLVYC
VCDHRRRDAE LTGRKDKDRA HDRRGSMNSV TKLTGLFETG AKDGRPEAIL TPLMHNGRLA
NGQMLIKADQ HHLDLSGMPT PESTPMQPRR KPGRGSREWE RNQNLINACT KDLPPMGSTV
ISTDLPLRAS PGHIPSVVVL PLPQHQQAYQ HEYVEQPRRG DLGPDDQGAT LEYKALKSHG
LGPAEDEGLP PRVPQREASL TVPPAVPQMG KRLEVHSSVY GHEYKRGYPV GPQKGSALKR
HNTNSSNSSH MSRHHSFNRV ETPPPAPQRV DSMHVTAQGM SLSRQSSVSS CGSLPRTGVK
HLKPDVPPKP SLVSLSAKVK SNDSCT
//
