ID A0A3P8YUP6_ESOLU Unreviewed; 700 AA.
AC A0A3P8YUP6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=SH3 domain-binding protein 1-like {ECO:0000313|Ensembl:ENSELUP00000020270.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000020270.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000020270.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000020270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_010893847.1; XM_010895545.3.
DR AlphaFoldDB; A0A3P8YUP6; -.
DR STRING; 8010.ENSELUP00000020270; -.
DR Ensembl; ENSELUT00000030646.2; ENSELUP00000020270.1; ENSELUG00000019508.2.
DR GeneID; 105025094; -.
DR KEGG; els:105025094; -.
DR GeneTree; ENSGT00940000158369; -.
DR InParanoid; A0A3P8YUP6; -.
DR OMA; ENHSQKG; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000265140; LG05.
DR Bgee; ENSELUG00000019508; Expressed in head kidney and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF12; BARGIN-RELATED; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 13..238
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 250..441
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 460..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 212..239
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 467..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..653
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..690
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 77713 MW; 934A6F2F48E2E937 CRC64;
MLKSFNLLKQ LGSVGKSQDA TDLLTEDLVM VEQRVEPAKR AAQIIHKKLM ACLQSQLGLD
SEKRMKKLPL MLLSVSMAES FKDFDADSSI RKVLEMCCFM ESHLASTLAD FELKLEKEVL
EPLNKLSEED LPEILKNKKL FAKLTMDWHS ARNRSLGSSG PQARQDGLRE EVEEAWRRLE
SIKDQYSADL YHFATKEDDY ANYFIRLLEL QAEYHKNSHD FLERNISELK ENHSQTESQE
YSSNGKVYGE PLLSHLYNSS REIAVPIQEC VHMLLHTGMR EEGLFRLAAA ASVVKKLKSS
LDRGVVNHSE FTDPHAVAGA LKSYLRELPE PLMTFDLYND WFKAAGEKEL EDKLTQFKAV
LKKLPSENYN NLRYLVQFLS CLSEQQAVNR MSPSNIAIVL GPNLLWPRVE GEAALLDMAS
ASSVQVVTVV EPLIQYSSSL FPEAVDFQVP ELPGVPDLHL STPECSETQK ERLSSTTSSS
SSCSSPCHPP LCKPSSSASQ DSGPFIVKSG SVVRRTTTWE NPASDLPGSN LTHLTPDLVR
TQSLSSVTIP AVVHNPSQPP SLKQTPSPTL LHSPPLVSGC SPTQKPVPDP SSLEPILEAP
PDSPRAVMKI DSPFKARRSF LQKKQPIQGK EQVVVAFFNP KVPPPPAPKE AAETQPQRPP
KGLNLPPKKA PSRKGPIRPP KIPPPKPPVL ESKQVTSIAQ
//
