ID A0A3P8YUS4_ESOLU Unreviewed; 510 AA.
AC A0A3P8YUS4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Transmembrane protein 200C {ECO:0000313|Ensembl:ENSELUP00000019893.2};
GN Name=TMEM200C {ECO:0000313|Ensembl:ENSELUP00000019893.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000019893.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000019893.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000019893.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM200 family.
CC {ECO:0000256|ARBA:ARBA00005308}.
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DR AlphaFoldDB; A0A3P8YUS4; -.
DR Ensembl; ENSELUT00000030147.2; ENSELUP00000019893.2; ENSELUG00000019176.2.
DR GeneTree; ENSGT00530000063698; -.
DR InParanoid; A0A3P8YUS4; -.
DR OMA; TVYSICR; -.
DR OrthoDB; 5309875at2759; -.
DR Proteomes; UP000265140; LG21.
DR Bgee; ENSELUG00000019176; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018787; DUF2371_TMEM200.
DR PANTHER; PTHR31815; AGAP005329-PA; 1.
DR PANTHER; PTHR31815:SF2; TRANSMEMBRANE PROTEIN 200C; 1.
DR Pfam; PF10177; DUF2371; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 15..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 56046 MW; B17559A22FE77180 CRC64;
MIATGGLLRI NRRQDSLRSK SRAENKRKRK AKKKRKNEVV VVKGKLNLCS ISGVVAAIGI
LILLVGIAMA ILGYWPRESL FHLDGDLASN NRSNGTGSEE PPKGFLAEFL DNYLYSDKLK
VFGPLIMGIG IFLFICANAV LHENRDKKTK IINLRDIYST VIDIHSLRTK ENTPLNGFVN
YVQSRGLEGK PSAVYTAALL AKGTWPSGDS PDEGSQGPSR CHSLTRSRVS SRERHSFTDT
VYTITRHSRA GQQSSPIPTP KPWETRTIAA SSVNAFTLPM TRSHRRANHH QRRPSAKAEA
GRSRAAMCDS GEEDGARVRR SVPETTTQAK VETLRMAMFL PQDSVEVYKS SGSLQEAPQG
SQVQLLPLSP AGPRVTGSHL SLSALTDCPQ SRDLGITSSS TTDWRVERSR RLSCPRLEVP
GGGGYIKLGN LGGESFESRE SCEVSAFSQV TSEEALTKRQ RDEGVSNEQE RSPGGAQDRG
SRRYSNKEKL LMISQSDSVL DDEEMESTDI
//
