ID A0A3P8YVL2_ESOLU Unreviewed; 413 AA.
AC A0A3P8YVL2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Microphthalmia-associated transcription factor {ECO:0000313|Ensembl:ENSELUP00000020611.2};
GN Name=MITF {ECO:0000313|Ensembl:ENSELUP00000020611.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000020611.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000020611.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000020611.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A3P8YVL2; -.
DR STRING; 8010.ENSELUP00000020611; -.
DR Ensembl; ENSELUT00000033478.2; ENSELUP00000020611.2; ENSELUG00000019860.2.
DR GeneTree; ENSGT00940000156326; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000019860; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18926; bHLHzip_MITF; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776:SF4; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 192..245
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 381..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 238..279
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 392..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 45898 MW; 17D1A77EF01B1751 CRC64;
MLETLEYHQL YQVQTHLENP TKYHIQQAQQ QQVKRYLGKL CSLPCPNQTC DHGMPPGPGN
SAPNSPMALL TLNSNFEKEM DDVIDDIISL ESSYNDDILG LMDPGLQMAN TIAANTNLLD
IYGNHGMPPP GLAINSCPAN LSNIKREYSV SQSPAIMHML DKAGSCGKFE NYQRPEGFPV
EAEVRAMAKE RQKKDNHNLI ERRRRFNIND RIKELGTMIP KSNDPDMRWN KGTILKASVD
YIRKLQREQL RAKELENRQK KLEHANRHLM LRIQELEMQA RAHGLNTASS ALSPAELSAR
GIKQEPALGD CHQDLYSVHP QHQHHPACTA DQAQSSTLEL NDVACSYTEG HGSDPGPYSA
HTKRSVKHND ILMDDTLSQV GAGDPLLSAV SPGASKDSSC SGSVSMEEND QSC
//
