ID A0A3P8YWE4_ESOLU Unreviewed; 292 AA.
AC A0A3P8YWE4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Glial cell line-derived neurotrophic factor-like {ECO:0000313|Ensembl:ENSELUP00000020252.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000020252.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000020252.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000020252.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832}.
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DR RefSeq; XP_019899365.1; XM_020043806.1.
DR AlphaFoldDB; A0A3P8YWE4; -.
DR STRING; 8010.ENSELUP00000020252; -.
DR Ensembl; ENSELUT00000030629.2; ENSELUP00000020252.1; ENSELUG00000019485.2.
DR GeneID; 109615175; -.
DR KEGG; els:109615175; -.
DR GeneTree; ENSGT00950000182993; -.
DR InParanoid; A0A3P8YWE4; -.
DR OMA; STWHALY; -.
DR OrthoDB; 4316464at2759; -.
DR Proteomes; UP000265140; LG03.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173:SF9; ARTEMIN; 1.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 177..291
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 292 AA; 32783 MW; 838512AB570ABA2F CRC64;
MLHIRPEARG GKGSELSGVR ADWTNTHEIS GGPGWRTSCR DGRGTTPIQS VGTPNPLRNW
KVLLWVVVSL LPLVEGARVG AGFGANLGQA LGMMGRMGER QFPDTLPEVD EEQEEERDPN
TPWYGLYDRS AMYEVDDNQR SLWGRRSPRN SDPSDADPKG SAKKKKKRKK KEKDKERDRK
SKGNGRKTQQ SSRDCRVEKR EMRVRDLGLG FDSDEIVLFK FCVGSCQSSR TNYDLALRAL
MLNGSLPRRT LRRVGAHPCC RPDRYEPVSF MDAHTTWQTI RSLSAASCAC VG
//
