ID A0A3P8YWQ7_ESOLU Unreviewed; 156 AA.
AC A0A3P8YWQ7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Insulin-like 3 {ECO:0000256|ARBA:ARBA00014427};
DE AltName: Full=Leydig insulin-like peptide {ECO:0000256|ARBA:ARBA00032881};
DE AltName: Full=Relaxin-like factor {ECO:0000256|ARBA:ARBA00032209};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000021006.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000021006.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000021006.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Seems to play a role in testicular function. May be a trophic
CC hormone with a role in testicular descent in fetal life. Is a ligand
CC for LGR8 receptor. {ECO:0000256|ARBA:ARBA00025288}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034}.
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DR RefSeq; XP_010892412.1; XM_010894110.2.
DR AlphaFoldDB; A0A3P8YWQ7; -.
DR STRING; 8010.ENSELUP00000021006; -.
DR Ensembl; ENSELUT00000031577.2; ENSELUP00000021006.1; ENSELUG00000020136.2.
DR GeneID; 105024263; -.
DR KEGG; els:105024263; -.
DR GeneTree; ENSGT00940000174859; -.
DR InParanoid; A0A3P8YWQ7; -.
DR OMA; QERIKIC; -.
DR OrthoDB; 5360690at2759; -.
DR Proteomes; UP000265140; LG03.
DR Bgee; ENSELUG00000020136; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00101; IlGF_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR043387; INSL3/INSL4.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR10423; INSULIN-LIKE 3; 1.
DR PANTHER; PTHR10423:SF3; INSULIN-LIKE 3; 1.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..156
FT /note="Insulin-like 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018290015"
FT DOMAIN 27..156
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 156 AA; 17012 MW; D03E7BCEFEDA432E CRC64;
MDAKCLLSLV VVVGLGMHAT QGQDARVKLC GREFIRMVVT SCGSSRLKRS TPDLGEHRTI
LDWLNSDQFA NMKTSETEVV RDVATPRDHQ DTTGSLNGDQ LTHLGFPSMP QQLQGDVESS
TIPLVYTVPS RTRRDAGPAG VCCRSGCTLS ELVQYC
//
