ID A0A3P8YXY2_ESOLU Unreviewed; 862 AA.
AC A0A3P8YXY2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Alpha-actinin-1 {ECO:0000256|ARBA:ARBA00018384};
DE AltName: Full=Alpha-actinin cytoskeletal isoform {ECO:0000256|ARBA:ARBA00041477};
DE AltName: Full=F-actin cross-linking protein {ECO:0000256|ARBA:ARBA00043249};
DE AltName: Full=Non-muscle alpha-actinin-1 {ECO:0000256|ARBA:ARBA00042871};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000021434.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000021434.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000021434.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR AlphaFoldDB; A0A3P8YXY2; -.
DR Ensembl; ENSELUT00000032114.2; ENSELUP00000021434.2; ENSELUG00000020638.2.
DR GeneTree; ENSGT00940000155548; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000265140; LG15.
DR Bgee; ENSELUG00000020638; Expressed in nose and 14 other cell types or tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF434; ALPHA-ACTININ-1; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 4.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 35..118
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 119..225
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 721..756
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 757..792
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 240..267
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 405..439
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 862 AA; 99524 MW; 8E49D1DC5E722E1C CRC64;
MPNFDMDPYD GDENNYMHQE DDWDRDMLLD PAWEKQQRKT FTAWCNSHLR KAGTQIENIE
EDFRDGLKLM LLLEVISGER LAKPERGKMR VHKISNVNKA LHYITSKGVK LVSIGAEETS
AKEGLLLWCQ RKTAPYKNVN IQNFHISWKD GLGFCALIHR HRPELIDYGK LRKDDPMTNL
NTAFDVAEKY LDIPKMLDAE DIVGTARPDQ KAIMTYVSSF YHAFSGAQKA ETAANRICKV
LAVNQENEQL MEDYEKLASD LLEWIRRTIP WLENRAPENT MQAMQQKLED FRDYRRQHKP
PKVQEKCQLE INFNTLQTKL RLSNRPAFMP SEGKMVSDVS NAWGGLEGAE KGYEEWLLNE
IRRLERLDHL AEKFRQKATI HEAWTEGKEE MLQARDFETA SLSDIKALLK KHEAFESDLA
AHQDRVEQIA AIAQELNELD YYDSPSVNAR CQRICDQWDA LGGLTQQRSE ALQRTEKLLE
TIDQLYLEFA KRAAPFNNWM EGAMEDLQDT FIVHTIEEIQ GLSTAHEQFK ATLPEADKER
GAILGIHNEI AKIVATYHVN MAGTNPYTTI NPQEINAKWD KVRQLVPQRD QALIEEHARQ
QNNERLRRQF ANQANVIGPW IQTKMEEIGR ISIEMHGTLE DQLTHLRQYE KNIVNYKPKI
DQLEGDHQLI QEALIFDNKH TNYTMEHIRV GWEQLLTTIA RTINEIENQI LTRDAKGISQ
DQMNEFRASF NHFDRKKTGM MEAEDFKTCL ISLGYNMGEA EFARIMSIVD PNRVGVVTFQ
AFIDFMSRET ADTDTADQVM ASFKVLAGDK NYILADELRR ELPPDQAEYC IARMAPYTGP
DAVHGALDYM SFSTALYGES DL
//
