ID A0A3P8YYK7_ESOLU Unreviewed; 390 AA.
AC A0A3P8YYK7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Hyaluronan and proteoglycan link protein 4 {ECO:0000313|Ensembl:ENSELUP00000021037.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000021037.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000021037.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000021037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR RefSeq; XP_010869874.1; XM_010871572.2.
DR AlphaFoldDB; A0A3P8YYK7; -.
DR Ensembl; ENSELUT00000041706.2; ENSELUP00000021037.1; ENSELUG00000020165.2.
DR GeneID; 105011506; -.
DR KEGG; els:105011506; -.
DR GeneTree; ENSGT00940000160926; -.
DR OrthoDB; 5402504at2759; -.
DR Proteomes; UP000265140; LG08.
DR Bgee; ENSELUG00000020165; Expressed in bone element and 6 other cell types or tissues.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd05877; Ig_LP_like; 1.
DR CDD; cd03519; Link_domain_HAPLN_module_2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR22804; AGGRECAN/VERSICAN PROTEOGLYCAN; 1.
DR PANTHER; PTHR22804:SF11; HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 4; 1.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 2.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 1.
DR PROSITE; PS50963; LINK_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00323};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..390
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018288305"
FT DOMAIN 47..160
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 164..259
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 264..356
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 210..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 309..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 390 AA; 43850 MW; 8EA47429001A746F CRC64;
MLVVHPLSLG TVTCLVLAFA LFATSLPTNV EKGRRKVVHV LEDDTGAVIV QTAPGKVVTH
RGGSITLPCR YHHEPEGSDP NRIRIKWTKV TDALVFEDVF VALGLQQRVF GSYQGRVSLE
QNGPGDASVI IHNITLEDYG RYECEVTNDM EDDTGFVNLD LEGVVFPYYP RVGRYKLNYQ
QAEDVCKEQD AILASHAQLH KAWLEGLDWC NAGWLEDGSV QYPISHPRDQ CGRKDTPAGV
RNYGYRHKED ERYDAFCFTS NLNGKVYFLK RFKKVNYAEA VKACVRDGSV VAKVGQLYAA
WKIQLLDRCE AGWLEDGSIR YPIVNPRTRC GGPQPGVRHL GFPDLKFRIY GVYCFRSNEE
NVNGVVGKPT RRPGKNSKDI QMNTTTTKTL
//
