ID   A0A3P8YYV2_ESOLU        Unreviewed;       682 AA.
AC   A0A3P8YYV2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Phosphatidylinositol binding clathrin assembly protein {ECO:0000313|Ensembl:ENSELUP00000021749.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000021749.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000021749.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000021749.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC       {ECO:0000256|ARBA:ARBA00008011}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8YYV2; -.
DR   Ensembl; ENSELUT00000032503.2; ENSELUP00000021749.2; ENSELUG00000020842.2.
DR   GeneTree; ENSGT00950000183068; -.
DR   Proteomes; UP000265140; LG07.
DR   Bgee; ENSELUG00000020842; Expressed in ovary and 15 other cell types or tissues.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR   GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   CDD; cd16985; ANTH_N_AP180; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.58.150; ANTH domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR014712; ANTH_dom_sf.
DR   InterPro; IPR045192; AP180-like.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR   PANTHER; PTHR22951:SF80; PHOSPHATIDYLINOSITOL BINDING CLATHRIN ASSEMBLY PROTEIN B ISOFORM X1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF89009; GAT-like domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          14..145
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   REGION          343..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          529..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..364
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..605
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   682 AA;  73710 MW;  E6BB9C69A5D0B26E CRC64;
     MSGQSITDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIHCTN EMNVNIPQLA
     DTLFERTANT SWVVVFKSLA ATHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
     STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GSDGVMRTVN TEKLLKTIPI IQNQMDALLD
     FNVNANELTN GVINAAFMLL FKDSIRLFAA YNEGIINLLE KYFDMKKTQC KEGLDIYKKF
     LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKV KDSTAASRAS
     TLSNAVSSLA NTGISFTRVD EREKQAALEE EQARLKALKE QRLKELQKGP PSSSTTAASP
     VSTDGCSVNT APAIDLFSTP STTNGTSKAA NDLLDLQPAF QQQALALSSG LPTANTWGDP
     FTSTEAVDDS IPNFNPFLTH PVVDAVHLPV VSSDGISSRT PSHEVFGDSF CGPASYPTTP
     LFQSEPPAVA GLFGGFSVSP TPLPQTARGL NVDFDSVFGN NSVSANSVDS AVASSSSQGL
     TPSGQQPGKL VSDDLDSSLA NLVGNLGIGN GVAKNDIHWS QPGEKKLTGG NNWQPKTAPS
     TTWNPSTLAP SVMAFPATTP TGMMAYGMPP QMGSMAMMTQ PTMMYSQPVM RPANPFGQAP
     GAQVPVYPIY SLSHISYIKG YR
//