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Database: UniProt
Entry: A0A3P8Z0M5_ESOLU
LinkDB: A0A3P8Z0M5_ESOLU
Original site: A0A3P8Z0M5_ESOLU 
ID   A0A3P8Z0M5_ESOLU        Unreviewed;       920 AA.
AC   A0A3P8Z0M5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Neutral sphingomyelinase activation associated factor {ECO:0000313|Ensembl:ENSELUP00000022305.2};
GN   Name=NSMAF {ECO:0000313|Ensembl:ENSELUP00000022305.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000022305.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000022305.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000022305.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P8Z0M5; -.
DR   Ensembl; ENSELUT00000042213.2; ENSELUP00000022305.2; ENSELUG00000021357.2.
DR   GeneTree; ENSGT00940000155059; -.
DR   InParanoid; A0A3P8Z0M5; -.
DR   OMA; LLKFPGC; -.
DR   Proteomes; UP000265140; LG21.
DR   Bgee; ENSELUG00000021357; Expressed in heart and 15 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0002233; P:leukocyte chemotaxis involved in immune response; IEA:Ensembl.
DR   GO; GO:0002232; P:leukocyte chemotaxis involved in inflammatory response; IEA:Ensembl.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR   CDD; cd06071; Beach; 1.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.10.1540.10; BEACH domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR000409; BEACH_dom.
DR   InterPro; IPR036372; BEACH_dom_sf.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR023362; PH-BEACH_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR   PANTHER; PTHR13743:SF123; PROTEIN FAN; 1.
DR   Pfam; PF02138; Beach; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM01026; Beach; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF81837; BEACH domain; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50197; BEACH; 1.
DR   PROSITE; PS51783; PH_BEACH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   TRANSMEM        25..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          195..292
FT                   /note="BEACH-type PH"
FT                   /evidence="ECO:0000259|PROSITE:PS51783"
FT   DOMAIN          296..581
FT                   /note="BEACH"
FT                   /evidence="ECO:0000259|PROSITE:PS50197"
FT   REPEAT          713..752
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          762..803
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          804..845
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          885..920
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   920 AA;  104662 MW;  CCDB6F057BFFFB14 CRC64;
     MANIVCFVSS LKYGRIMLEP GNSSTISVCV SVESIIMFLG LVTLILCCLC SRFSLLLLDL
     EEYYFEQHTV HHVTTISDKK RKIRGSLKIC SKSIIFEPEE HVEPILKIPL RDCKKIEVYL
     IKECNVVAPY RVERGDRTFL FYLEILSKTE DIVQTLLQLY RASCLDKLGD QTAMIAANLQ
     SRLARTSFDK NCFQNVAEIP HMECEAEMVT PLVTNPGHVC ITDQSLYFQP LNGYPEQVVR
     IELHRVKRIY KRRHGLRPLG LEVFCTENDF CSDIYLKFYQ TSDRNDLYYY IATFLENHMA
     EHTAESYMLQ WQRGHLSNYQ YLMHLNNLAD RSGNDLSQYP VFPWIIADYS STELDMMNPA
     TFRDLSKPVG ALNKERLERL LSRYRDMPEP RFMYGSHYSS PGYVLFYLVR VAPEHMLCLQ
     NGRYDNADRM FNSIGETWKN CLEGATDFKE LIPDFFGNDP SFLLNRQNLD LGKRQDGSSV
     QDVDLPPWAA DASDFLQKSQ KALESQYVSE HLHEWIDLVF GFKQRGSEAV AAQNVFHPLT
     YEGGIDCDSI EDPDQKIAML TQILEFGQTP TQLFTTPHPQ RITPRFQSIS RTPSVNTPLN
     DEDSFEDLTE ESRRLAWNNI AKLKLISSHK IHKEAVTGIA VTRSASSVFT TSQDSTLKMF
     SRESNGLQRS MSFSNMALSS CLMLPEDKAV VCSSWDNNVY FYSIPFGRRQ DTLMGHDDAI
     SKMCWRDNQL YTASWDSTVK VWQCDSADIA NNKRCQFQLL AEFEHEAGVN TISLNPAGTL
     LVSGTKDGTA SIWDTSSLAQ LHQVHCHSGK IHDVAFSPDS RHILSVGEDS CLKVIDVQTG
     MMISSVQADE EQRCFCWDGN TVLSGGQSGH LQVLDLMSNK VITRIPGHSG AVTAMWMNEQ
     CSTVITGGED KQVIFWKLDC
//
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