ID A0A3P8Z0M5_ESOLU Unreviewed; 920 AA.
AC A0A3P8Z0M5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Neutral sphingomyelinase activation associated factor {ECO:0000313|Ensembl:ENSELUP00000022305.2};
GN Name=NSMAF {ECO:0000313|Ensembl:ENSELUP00000022305.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000022305.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000022305.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000022305.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8Z0M5; -.
DR Ensembl; ENSELUT00000042213.2; ENSELUP00000022305.2; ENSELUG00000021357.2.
DR GeneTree; ENSGT00940000155059; -.
DR InParanoid; A0A3P8Z0M5; -.
DR OMA; LLKFPGC; -.
DR Proteomes; UP000265140; LG21.
DR Bgee; ENSELUG00000021357; Expressed in heart and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0002233; P:leukocyte chemotaxis involved in immune response; IEA:Ensembl.
DR GO; GO:0002232; P:leukocyte chemotaxis involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF123; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..292
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 296..581
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 713..752
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 762..803
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 804..845
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 885..920
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 920 AA; 104662 MW; CCDB6F057BFFFB14 CRC64;
MANIVCFVSS LKYGRIMLEP GNSSTISVCV SVESIIMFLG LVTLILCCLC SRFSLLLLDL
EEYYFEQHTV HHVTTISDKK RKIRGSLKIC SKSIIFEPEE HVEPILKIPL RDCKKIEVYL
IKECNVVAPY RVERGDRTFL FYLEILSKTE DIVQTLLQLY RASCLDKLGD QTAMIAANLQ
SRLARTSFDK NCFQNVAEIP HMECEAEMVT PLVTNPGHVC ITDQSLYFQP LNGYPEQVVR
IELHRVKRIY KRRHGLRPLG LEVFCTENDF CSDIYLKFYQ TSDRNDLYYY IATFLENHMA
EHTAESYMLQ WQRGHLSNYQ YLMHLNNLAD RSGNDLSQYP VFPWIIADYS STELDMMNPA
TFRDLSKPVG ALNKERLERL LSRYRDMPEP RFMYGSHYSS PGYVLFYLVR VAPEHMLCLQ
NGRYDNADRM FNSIGETWKN CLEGATDFKE LIPDFFGNDP SFLLNRQNLD LGKRQDGSSV
QDVDLPPWAA DASDFLQKSQ KALESQYVSE HLHEWIDLVF GFKQRGSEAV AAQNVFHPLT
YEGGIDCDSI EDPDQKIAML TQILEFGQTP TQLFTTPHPQ RITPRFQSIS RTPSVNTPLN
DEDSFEDLTE ESRRLAWNNI AKLKLISSHK IHKEAVTGIA VTRSASSVFT TSQDSTLKMF
SRESNGLQRS MSFSNMALSS CLMLPEDKAV VCSSWDNNVY FYSIPFGRRQ DTLMGHDDAI
SKMCWRDNQL YTASWDSTVK VWQCDSADIA NNKRCQFQLL AEFEHEAGVN TISLNPAGTL
LVSGTKDGTA SIWDTSSLAQ LHQVHCHSGK IHDVAFSPDS RHILSVGEDS CLKVIDVQTG
MMISSVQADE EQRCFCWDGN TVLSGGQSGH LQVLDLMSNK VITRIPGHSG AVTAMWMNEQ
CSTVITGGED KQVIFWKLDC
//