ID A0A3P8Z3Z2_ESOLU Unreviewed; 688 AA.
AC A0A3P8Z3Z2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Protein numb homolog {ECO:0000256|PIRNR:PIRNR017607};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000023524.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000023524.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000023524.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the process of neurogenesis.
CC {ECO:0000256|PIRNR:PIRNR017607}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR017607};
CC Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR017607};
CC Cytoplasmic side {ECO:0000256|PIRNR:PIRNR017607}.
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DR RefSeq; XP_012993037.1; XM_013137583.2.
DR AlphaFoldDB; A0A3P8Z3Z2; -.
DR Ensembl; ENSELUT00000042728.2; ENSELUP00000023524.1; ENSELUG00000022404.2.
DR GeneID; 105015904; -.
DR GeneTree; ENSGT00940000156005; -.
DR OrthoDB; 2913102at2759; -.
DR Proteomes; UP000265140; LG15.
DR Bgee; ENSELUG00000022404; Expressed in heart and 15 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR CDD; cd01268; PTB_Numb; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016698; Numb/numb-like.
DR InterPro; IPR010449; Numb_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR47368; NUMB; 1.
DR PANTHER; PTHR47368:SF5; PROTEIN NUMB HOMOLOG; 1.
DR Pfam; PF06311; NumbF; 1.
DR Pfam; PF00640; PID; 1.
DR PIRSF; PIRSF017607; Numb/numb-like; 1.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR017607}; Membrane {ECO:0000256|PIRNR:PIRNR017607};
KW Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 37..162
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..251
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..354
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 73872 MW; E5C73B43DED8935C CRC64;
MNKLRQSFRR KKDVYVPESS RPHQWQTDEE AVRSGKCSFA VKYLGHVEVE ESRGMHICED
AVKRLKTAGK KAVRAVLWVS ADGLRVVDDK TKDLILDQTI EKVSFCAPDR NFERAFSYIC
RDGTTRRWIC HCFMAIKDSG ERLSHAVGCA FAACLERKQK REKECGVTAT FDANRTTFTR
EGSFRVTTAT EAAEREEVMR QLQDKKAENH VNSSVPVTSG PSVGVVNQAV TPLTGPPSPP
SSSPPLGPST HGPQVIPRRH APVETLARQG SFRGFPALNN KSSPFKRQLS LRMNELPSTM
QRKSDFPMKN TVPELEGEGD SISSLCTQIT SAFSGPPEDP FSQAPMPRPA SSPQSPGAPA
GAQPDNQDML ACTTRTTTTS SLLSATLFAP RSAVVNGSEP LFHPSTANHP AMAPPLPARD
TNPWAEAPAS SSSTHPGGDW TTPVIVAPPS AAASPSHHSH RRTPSEADRW LEEVTKSVRA
PQPASSHTSQ NLLAPNPPAF SAPPAQAFSA TPFPAPMPVA SAAPVAFMPA VPLAVPLLPP
RQPSYQTPAP YPMSNGLSYG QPSVPVVGIT PSQMVANVFG SATQPQAYPV TQYDPAQHAV
GVPFINPPQV PLQPPNGSLA FNGVAGDGWA PPSLPPPSSP APPLPPQPAA DPFEAKWAAL
ESRSRQRTTP SPTNPFSTEL HQTFEIQL
//
