ID A0A3P8Z5D9_ESOLU Unreviewed; 210 AA.
AC A0A3P8Z5D9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Prolactin {ECO:0000313|Ensembl:ENSELUP00000023412.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000023412.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000023412.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000023412.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003618}.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000256|ARBA:ARBA00008474, ECO:0000256|RuleBase:RU003618}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_010899486.1; XM_010901184.3.
DR AlphaFoldDB; A0A3P8Z5D9; -.
DR STRING; 8010.ENSELUP00000023412; -.
DR Ensembl; ENSELUT00000034590.2; ENSELUP00000023412.1; ENSELUG00000022249.2.
DR GeneID; 105028434; -.
DR KEGG; els:105028434; -.
DR GeneTree; ENSGT00950000182818; -.
DR InParanoid; A0A3P8Z5D9; -.
DR OMA; SALMCKA; -.
DR OrthoDB; 4147820at2759; -.
DR Proteomes; UP000265140; LG11.
DR Bgee; ENSELUG00000022249; Expressed in spleen and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417:SF5; PROLACTIN; 1.
DR PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hormone {ECO:0000256|RuleBase:RU003618};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..210
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018335546"
SQ SEQUENCE 210 AA; 23416 MW; 499648262787553B CRC64;
MAHQSQLSKL YLAVLCLAVS CHAIGLNELM ERASQRSDKL HSLSSSLTND LDSHFPPMGR
AMMPRPNMCH TSSLQTPMDK EEALSVSEND LISLARSLLL AWNDPLSLLS SEATTLPHPS
KSIISSKIQE LQDYSKSLGE GLDVLVNKMG PSSQNISLMP FRGAELGQDK TSRLINFHFL
MSCFRRDSHK IDNFLKVLRC RAAKMRPEMC
//
