ID A0A3P8Z7L8_ESOLU Unreviewed; 5013 AA.
AC A0A3P8Z7L8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=SCO-spondin {ECO:0000256|ARBA:ARBA00020523};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000024202.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000024202.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000024202.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR STRING; 8010.ENSELUP00000024202; -.
DR Ensembl; ENSELUT00000035592.2; ENSELUP00000024202.2; ENSELUG00000023199.2.
DR GeneTree; ENSGT00940000155829; -.
DR InParanoid; A0A3P8Z7L8; -.
DR Proteomes; UP000265140; LG21.
DR Bgee; ENSELUG00000023199; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00112; LDLa; 7.
DR CDD; cd19941; TIL; 13.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 25.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF402; -; 1.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF01826; TIL; 12.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 23.
DR Pfam; PF00094; VWD; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00832; C8; 3.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00209; TSP1; 26.
DR SMART; SM00214; VWC; 7.
DR SMART; SM00215; VWC_out; 9.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF57567; Serine protease inhibitors; 13.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 25.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS50092; TSP1; 26.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 3.
DR PROSITE; PS51233; VWFD; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 193..364
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 552..725
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1011..1181
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1334..1394
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1926..1988
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 2015..2163
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 4853..4909
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 4920..5007
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 2228..2279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2339..2361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3927..3946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1374..1386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1381..1399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1416..1428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1423..1441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1435..1450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1452..1464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1459..1477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1471..1486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1492..1504
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1499..1517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1551..1563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1558..1576
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1570..1585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2311..2323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2318..2336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2330..2345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2364..2376
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2371..2389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2383..2398
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 5013 AA; 543504 MW; 39E209E1F5F5BF5E CRC64;
LEQLNVTIFT QYRVLQHWCE HRVEESVEHI ISPRLQREVD CSQVYHYNTN GWRLDVDRMR
HHHGGDDGIA LYYRQLGPKA VCFLYKPALM ETQKVNRTMR GCCEGWGGSR CSLGVGARGQ
CFSTWNCEDF PGVHNSSLMA MEQCCGSQWG LSWRNSSDQT CLSCTYTLLP DSQSSPLVRG
GLLGSARNPQ GSATCLSWGG AHYRTFDRKH FHFQGSCTYI LASSTDGTWA VYISTVCNGR
GDCSKALRMM LGLDLVSVHL SNLTLNGLLV PKGEPLFQNG VSVHWLGDFV FVESGLGVRV
KFDMGNTVFL TVTTEHLATT RGLCGVYNSN ADDDFTTMSG TVSQYAASFG NSWRVPDQQT
EGCDDAAELG HSCDMTGDAA LRREAELVCH RLLESPFIQC HHRVEPVAYV DSCLYLHCSL
GTREREAATC DTLASYAREC AQQHVVISWR SSGVCERVCP QGQVFSDCVS SCPPSCSSPQ
PPASGQCREE CVGGCECPRG LYLHQGLCLR RDDCPCFHRR HTYQSGDTIQ QRCNTCVCRA
GVWQCSGERC AAQCSLMGAL HVSTFDRKRY SLQGGDCGLT VVEDFVDRKL VVSVEGGECV
TGGRYGCLRE ISVTALRTTV IITSTGLVTV NGQREALPVV TGDLVVRKAS SSFLVVQAFG
AQLLWHLDGP LALITLQPGF AHKVRGLCGT LNWNQYDDFT TPEGDVENTV SSFAAKFTTR
DCPPPLEAQP DPCGTYTQRR QYAQRVCSVI RSPVFQPCHD VVEKEPYLRL CLMDVCGCEP
PRHCHCTILT TYALHCAQEG VPVSWHNHTF CPVQCSGGQV YQECGRPCGG SCADLRQGWS
CDQGTRSCVP GCQCPPGLAQ DEQGQCVPVS MCPCMRGDKL YQPGSTVHDN CNTCVCTRGV
WNCTDDVCQE VSQCPGSLVF SPHSCLLTCS SLDTPGQGPA GAPTSSCQEP LAGCVCPQGT
VLLDARCVLP EKCPCHHNGR LYYNNETIAK DCNTCVCKDR RWHCSQSLCA GTCLATGDPH
YITFDGRCFS FLGDCEYVLA QEAGGLFSVT AENIPCGSTG VTCTKSVTLS VGNTAIHLLR
GKAVTVNGMA VTLPRMYSGS GLTLERVGLF VSVSSRLGVT LLWDGGMRVY VRLAARLRGR
VGGLCGNFDG DTENDFTTRQ GIVESTAELF GNSWKVSPSC PDVTDQDLRD PCAINPHRVT
WARQRCAVIT QDLFSPCHPE VPYQQFYDWC VFDACGCDSG GDCECLCTAV SAYAEECNRR
GIYIRWRTQE LCPMQCENGL VYEACGPACS PTCPSVAQSP DSKCGALSCV EGCFCPTGTV
LHGGVCVAPA LCPCDWEGSV FPPGAVVSQR CQNCSCNEGV WACEGSPCPS PPPCQESEFR
CAAGRCVPAL WVCDNEDDCG DGSDELCPST YCGVVCGDGE FMCSGGRCVL YIHRCDGHDD
CGDLSDERGC VCAPGELQCP GDQCVPADRV CDGHRDCPSG TDEAVCPDEV TCAPGQFLCA
DGTCVTPNKL CDGVADCQGA EDEDQINCSP VTMAPAITET PITPTAINTA CRPYEFGCAN
GQCVPRAWHC DGETDCVDGS DEQGCSWRCG PGQVACLGGD QCVDYRLTKP SPGPTEKNIS
QTCPEFTCLD GSCVCNGMAD CSDSLLEPLR SPSDEQGCRS WTPWGPWSSC SHSCGTGYTS
RQRQCPLGDA LGQCRGEDRQ REQCFSTSCP VDGQWLPWVT WSNCSEGCEG VAVRQRTCIP
PQNGGRDCTQ LPGESAFATE IKPCPQDDCA NVTCPSGLVR LSCAPCPMSC AHVSSGTVCD
PAVACFSGCW CPEGWVMNHT QQCVLPEECV CEVSGVHYLP GQEVKVDCEI CTCERGRPQH
CRPNPECSVH CGWSSWSAWG ECLGPCGVQS VQWSFRSPNN PSNHGKGRPC RGIYRKARRC
QTDPCEECEF HGQSHAVGDR WKTGQCLLCH CLPNLVVQCA PYCPHTATGC PQGQRLVPEE
GSRCCFCEGK QSPPTICFPL FTALDLMINM NLNECWTPLG IQSLPDSSFS ASSHQWGHPP
QAGRLYARDP HKDLQGWTVQ TPYLQLDLLR PHNISGVLTQ GGGAFDTFVS SFFLQFSNDG
KQWDTYQELI TDARPRAKVF SGNSDDQSVS YSRLDRVVSA QFVRVLPHNF KNSIFLRVEL
MGCGDGLFVY AFTCSRVYGL EKMHVYHRGI EIQNKPFRYF IYGPFYPLMR NATFRLNQYI
SLCTGTTPSK GQPGIHTKEP QDGRPGIATT GSPGLSPDSS GGTGEPGVHR ITSPESGQMT
SSTSHFYAFV SSPALWISTT TNDGGLPRVL CVEGQFSCRL FGCVDAEAVC NGHQDCVDGS
DEDQCGTTPR PALTTSRPAP PSPCSPKQFS CSSGECVHLD KRCDLRRDCA DGSDERDCVD
CIMSAWTGWS QCSVTCGLGS LFRQREVLKE ALSGGTCGGA QFDSRACFPQ ACPVAGHWSE
WTSWSPCDAQ CGGGLRVRNR TCSNPPPKNG GADCEGMRLQ TISCNSQPCA SDVFAVSGCA
NGMVLVSPTD CQAGVVESCP PACLHLHYSN CTSPCITGCR CPAGFFLQEG RCVTASQCVC
HWEGLALQPG QEVKKDNCST CVCENGRVSC DNSSCVASCD WSAWSSWTPC DSSCGAGLQQ
RYRSPVSPRG VSRVQPCPGD SSEARQCFGP CPPGKEVLWG EWTAWSQCSK TCFLHVDDVG
LRRRFRTCNL TQSYTHALTH MFCEGESEEQ EHCNTLHCAV NGGWSAWSPW SLCSSECDSG
AQTRERFCSS PAPQHGGSTC PGPHIQTRDC NSHLCSGTVC PEGMAFMSKE QCRAHGGACP
RMCLDVTSAV ECATECYDGC YCALGLYLLN TTCVPVSQCP CYYQGNVYLE GAVVKLDHCN
NCTCRSGEME CGTTPCPVDC GWSSWTPWSA CSRTCDVGVR RRYRSGTNPA AAFGGRVCRG
DRVGMDTCSL EPCQGVKEPW SVWSECSVTC GGGYRNRTRG PQRTHGTAQQ FSACNLQPCG
NGTACPGGQV WTVCVEGPVT CSDISMDYDR NCTPGCQCPH GTVLQDGKCV PVSQCRCDVN
GEQYEPTHVV SRDCNNWYCY ATWLTLSTTP FTVDGQWSSW TPWGQCSVRC GPGLQSRYRF
CSSPRRSGSG LPCIGPDRQD QLCMTASCDR DGGWGDWSNW TDCTKSCGGG VQSRRRECDS
PSPVREGDYC EGLGTEIMTC NTDHCPVAPC SQVPGTVFSN CGPSCPRSCD DLAHCEWLCE
AGCYCTEGKV LSDNGTSCVN REECPCLDLN TGLRLRPGET TTAPDGCNNC TCERGRLNCT
ADPCPVSGGW CDWSEWTPCS KTCGAEWVSR YRSCDCPKPK AGGAPCLGEQ EVHGGVGVQI
QRQPCPVVTF CPVHGSWGLW SAWSECDGCE GVSVRTRGCD SPPARFGGLP CHGGSRQRRG
CHDNTTICSD CLGRQVNWPC GKPCPRSCSD LHGDTECVDS VECSMTCGCP ANQVLQDGQC
VEREECRCKF HNSTTGGFSG LDSSNTSWVR PGKSDWQFAN PGETIISDCK NCTCEAGVLN
CQSVPGCHVD GDTGRWLPWS SWTMCSVSCG GGEQYRTRDC SSPPCSGMKR QSKTCNTQVC
LDVGCPPGRL YRECERGEGC PFSCAQVSGR EGCYSEGCEE GCHCPPKTFH HNGACFQECP
CVVDKDFLTS VQNVSVTPVL ANHNLTQGSM FQSGEMFLHD CSACECRHGL WNCTLELCPV
DGGLSPWGPW TQCSLSCGGL GLKTRTRACS HPAPARGGRD CLGPRQESTY CQAPDCPDED
AGFSQWSSWT SCSRSCSDSL TPALKSRRRH CVRPHCSGET LQQKACNLPQ CPGACVGDDC
AQRNCTWTGW GEWTACSRSC GVGQQQRLRT FLPPGVNGSW CGDILGGNQD NRFCNIRACR
VDGGWSRWSP WSLCDKRCGG GRSVRTRSCS SPPPKNGGNK CEGEKNQVKP CNTKPCDEKG
CPAGQVFVPC ANECPQRCSD LQQGIQCQGN SECQSGCRCP KGQLQQEGVC VQVWQCDCLD
SLGQGWAAGS WHQVDCNNCS CSDGLLSCTN QSCQEASCTW SSWSNWASCS STCGRGKRSR
FRSQIQESEG VGCQAEEVQH KSCDPGPCPP LCVHDNQELT VGDTWLQGEC KQCTCTPEGD
YCQGVDCRVD GGWTPWSVWS DCPVTCGRGN QIRSRACINP PPRNNGTHCS GSEREAQDCR
APPCLDDLCP WSPWTPCSRS CGAGVLSRRR VCACEEERRG EGACPPEVEA ERNREETQLC
YKRLCPDCPM SEWTEWSACS CVSPRQQRHR APLSPATGGQ QCSLLDTQSR TCSLDRCDDS
CEKPFQYSAC GAPCEKQCVL QGQKEPCAGL GECTPGCYCP EGFLQQNGTQ CVPPEQCGCV
YLQHLASGRP VSVIVPQGAI VPIGCSTCLC HDGTLQCDMR ECEVILSEWS EWTPCSPCAP
ASSLLPSSSP TGGAAPLVSV QRRYRACLDL DSGQPVSGKE AEEQCLEELE EERLCSDPNA
CRDLCQWSVW SAWSVCQDPC SGGVRQRHRQ PQASPPGPQC RMQETQTQSC NTGLCPGESC
EDRGRVYHGA CANECPRSCT DLWEHVQCLQ RACHPGCRCP DGWLLQDGDC VQVSECRCGV
PMGNGTLEIS PAENLTLDCN TCVCANGILV CTKLPCPIYH PWGQWSTCSA SCGSGKRTRT
RPCNDTDGGP PCAETIHTET CLLPPSCPPG QLFSHCAGPC PYSCEDLWPE NQCVPGPCIP
GCTCPSGMVL NNGSCVLPDL CPCSLRSLPG TLNMTLDDRK EVAPGTVLHH LSCPNGERWA
RSVSEALSVC ERSCEEIYLA VPHNCSSNEG CVCEEGLYRN TEGRCVIPAL CPCEDEGTLR
EAGSEWGDGC LMCRCVNGQK RCRSGCPPLQ CEEGEVKVED PGSCCPICRK EFIVEPVAEC
RRYTEVRNIT KGDCRLDNVE VSYCRGRCLS KTDVILEEPY LQSLCDCCSY RLDPESPVRF
LSLLCDSGES EPVVLPVIHS CECTSCHGGY SPL
//
