ID A0A3P8Z8X7_ESOLU Unreviewed; 581 AA.
AC A0A3P8Z8X7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Perforin 1.2 {ECO:0008006|Google:ProtNLM};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000024682.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000024682.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000024682.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3P8Z8X7; -.
DR Ensembl; ENSELUT00000043229.2; ENSELUP00000024682.2; ENSELUG00000026935.1.
DR GeneTree; ENSGT00530000063725; -.
DR Proteomes; UP000265140; LG24.
DR Bgee; ENSELUG00000026935; Expressed in head kidney and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF3; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 13..362
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 377..499
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 581 AA; 64925 MW; 8454A401F6771BE5 CRC64;
KRHIPVYIRS HSTQIECSAA QSAPGTNLAG EGFDVVTMER KQAYVVNMDN WSKTQNGTCT
LCVNPFMEGQ TQRLPVAVVD WRPSHQCHMK ISSTVYDSSE AFVSQNASWK TGLNVITTKV
KGSVMVGGTH SRTARRVMDQ SKQDKYSFIK QETHCSYYSY RLIEDPPLHP EFSRSLGLLP
PLYTPQTKAE YTRFLDIFGT HYIRKVQLGG RVKSVTSLRV CEASLKGYKE NEVKDCLEAE
ASGATHTGTV KVNAETKFCK KELKSRDTKD TFSSMFNDRF TEVVGGQTDG ATDLLFSRTG
GTSKGFSDWT KTLKTVPDII NYSLHPLHLL VKRTKKRAGL KKAVEDYILE HALVKHCSGK
CKSGSNPSTH DSCQCVCQAS KEMTNQCCPQ EKGLARLKVT MMYAKDLYGD TNSETDGFVK
VVMGAVTKQT GVIYNNDNPR WDETFVFNTV KLSLASELKF KVYDKDKGWF NGNDDLLGEC
TVRPVKAGSY NYEMCSLYHG NLFYSYMVEC FPGLGGPTCG EYMPSPMNSD LSGIYTSRNA
LNMTQDLLAH IRMGRPPVDP LAFMMKQKAN DHSLLSALNE L
//
