ID A0A3P8Z950_ESOLU Unreviewed; 204 AA.
AC A0A3P8Z950;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Erythropoietin {ECO:0000256|ARBA:ARBA00015421, ECO:0000256|PIRNR:PIRNR001951};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000025235.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000025235.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000025235.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC regulation of erythrocyte differentiation and the maintenance of a
CC physiological level of circulating erythrocyte mass.
CC {ECO:0000256|PIRNR:PIRNR001951}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR001951}.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC {ECO:0000256|ARBA:ARBA00005782, ECO:0000256|PIRNR:PIRNR001951}.
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DR RefSeq; XP_010901757.1; XM_010903455.2.
DR AlphaFoldDB; A0A3P8Z950; -.
DR STRING; 8010.ENSELUP00000025235; -.
DR Ensembl; ENSELUT00000036878.2; ENSELUP00000025235.1; ENSELUG00000023933.2.
DR GeneID; 105029895; -.
DR KEGG; els:105029895; -.
DR GeneTree; ENSGT00390000017226; -.
DR InParanoid; A0A3P8Z950; -.
DR OMA; AMEFPRL; -.
DR OrthoDB; 4338688at2759; -.
DR Proteomes; UP000265140; LG24.
DR Bgee; ENSELUG00000023933; Expressed in stomach and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005128; F:erythropoietin receptor binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-UniRule.
DR GO; GO:0048823; P:nucleate erythrocyte development; IEA:Ensembl.
DR GO; GO:0048793; P:pronephros development; IEA:Ensembl.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003013; Erythroptn.
DR PANTHER; PTHR10370; ERYTHROPOIETIN; 1.
DR PANTHER; PTHR10370:SF0; ERYTHROPOIETIN; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PIRSF; PIRSF001951; EPO; 1.
DR PRINTS; PR00272; ERYTHROPTN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001951-1};
KW Erythrocyte maturation {ECO:0000256|ARBA:ARBA00023057,
KW ECO:0000256|PIRNR:PIRNR001951}; Hormone {ECO:0000256|PIRNR:PIRNR001951};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|PIRNR:PIRNR001951}.
FT DISULFID 51..199
FT /evidence="ECO:0000256|PIRSR:PIRSR001951-1"
FT DISULFID 73..77
FT /evidence="ECO:0000256|PIRSR:PIRSR001951-1"
SQ SEQUENCE 204 AA; 22479 MW; 2B1D3B691B505411 CRC64;
MGNRRAKGRN GEDPVRDYVD SDMEAPRLLT LLLMLLEWTR PGRASPLRPI CDLRVLKHFI
EEAKDAEAAM LTCKEGCGLP EPVTVPQTKV DFNVWERKNA PEQAKEVQSG LWLLSQAVGS
LRGSVTDATL HSHIDNSLRN IFSIGQVLRS LNFQEYPPPG VGVSGAETWR VSSASELLQV
HVNFLRGKVH LLLSNAAVCQ QGGS
//
