ID A0A3P8ZAB3_ESOLU Unreviewed; 304 AA.
AC A0A3P8ZAB3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Tumor necrosis factor receptor superfamily member 6B {ECO:0000313|Ensembl:ENSELUP00000025716.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000025716.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000025716.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000025716.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_010878717.1; XM_010880415.3.
DR AlphaFoldDB; A0A3P8ZAB3; -.
DR Ensembl; ENSELUT00000037458.2; ENSELUP00000025716.2; ENSELUG00000024407.2.
DR GeneID; 105016518; -.
DR GeneTree; ENSGT00940000155167; -.
DR OrthoDB; 5348767at2759; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000024407; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR048522; Death_3_fish.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR23097; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER; 1.
DR PANTHER; PTHR23097:SF181; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21-LIKE-RELATED; 1.
DR Pfam; PF21733; Death_3; 1.
DR Pfam; PF00020; TNFR_c6; 3.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..304
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028380046"
FT DOMAIN 58..99
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 58..99
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REPEAT 100..136
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 100..136
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REGION 281..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 59..74
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 81..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 118..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 304 AA; 34561 MW; 2D53364F5AF3AE96 CRC64;
MLFPILVALA AVQPSCGSLQ TYQYQEPITN KLLTCDRCPP GFHMLKDCTS ATPTVCKPCP
PNHYTQYWNY LPRCLYCSTF CGENQRVKEE CSSQNNRVCE CEEGFYSDTG FCIRHKECPP
GHWVKQRGTT ETDTECEKCP HGYFSRNFSS SAGCANHTDC ESLGRKTVIR GTCWHDNICA
NSCEELKDGG ELLLFRTFLP DFFQFHEMRT SMVRKLIGTL NGEEEQPHYR GLLLNKLRDW
FTDATVEELR SLPKVLRKLD LVLAGRLERK MRMLNGASDC NQNINVTPPP HCEAEDSSPT
ESGI
//
