ID A0A3P8ZBD9_ESOLU Unreviewed; 891 AA.
AC A0A3P8ZBD9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SH3 and PX domains 2B {ECO:0000313|Ensembl:ENSELUP00000025582.2};
GN Name=SH3PXD2B {ECO:0000313|Ensembl:ENSELUP00000025582.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000025582.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000025582.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000025582.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8ZBD9; -.
DR Ensembl; ENSELUT00000037294.2; ENSELUP00000025582.2; ENSELUG00000024231.2.
DR GeneTree; ENSGT00940000158396; -.
DR Proteomes; UP000265140; LG07.
DR Bgee; ENSELUG00000024231; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF2; BUD EMERGENCE PROTEIN 1; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 4.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 2..126
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 148..207
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 216..275
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 350..409
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 830..891
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 289..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..719
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..786
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 891 AA; 98706 MW; 4D116710F3F8300A CRC64;
MQNISHVPRI GVIDVTSLKK KYVYIIKVSW SDGSTEVIFR RYSKFFDLQM ELLDKFPVEG
GQKDPKRRII PFLPGKILFR RSHIRDVAMK RLRPINEYCR ALIQLPVYIS QCEEVRVFFE
TRPEDLNPPK EEPITKKKSG DSISADPLLL DQYVAVTDYE KQESSEISLH VGQTVEVIEK
NESGWWFVSS DEAQGWVPAT CLEAQDDPDD FSLPGEEEER YTVIYPYSAR DQDEIDLESG
MTVEVIQKNL EGWWKIRYQG QEGWAPASYL KKADILSQKL AAGVAGHAST NELDGFPKQQ
SQAKESRGDR EQKDKGFSPF KQGARQRPPP RRDLSIPRGQ NLPKPPTPPQ VEEEFYTIAD
FQTTIPDGIS FQAGVKVEVI EKNSSGWWYI QIEDKEGWAP ITFIDKYKKT SLTPRPNFLA
PLPNEMAQLK LEDGPASGAE QEDSWSKPLP DEPTTSSDSA ARPKLRDWKS SASKGASAFS
GPLPPAPSAP PAEEKPALPP RRESINKSLD IEITVEKPRP DLSKPLPPKP PAPGVIMPLL
APKAAPFKPD KPPEPKREAA NKPLHLKNEM GLECGHKISA KEVKKFNLKP VAKQPLKPKP
DPPEEKPEAA GPALFMKPKP IVRPKPVPAA KPESPAENKL DITNLRSKLK PSKPAEPAEP
GTGSAELSHQ NGTTANNAPS SALPKIPPSN VPPKMPPPNN VLPKMTRPSS PPGNAPSKLP
PAPFALNNGK ASDEPALLPR RPPPPKKTSE PSSPTETRAP LKELPDTKPA LTQLGRPPPP
KPKAFVPPPP KDREKEETKA KVPVAPKPQV KSEKPGPPRD KLPPLIKEPS KEELFLAVAD
FEGDDQTAGF KEGTVFEVME KNSSGWWFCK NLGEGPMKEG WIPSNYLTKK P
//
