ID A0A3P8ZC72_ESOLU Unreviewed; 919 AA.
AC A0A3P8ZC72;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase-like N {ECO:0000313|Ensembl:ENSELUP00000026280.2};
GN Name=PTPRN {ECO:0000313|Ensembl:ENSELUP00000026280.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000026280.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000026280.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000026280.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
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DR AlphaFoldDB; A0A3P8ZC72; -.
DR Ensembl; ENSELUT00000018923.2; ENSELUP00000026280.2; ENSELUG00000002114.2.
DR GeneTree; ENSGT00940000154095; -.
DR Proteomes; UP000265140; LG22.
DR Bgee; ENSELUG00000002114; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..919
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027685483"
FT TRANSMEM 504..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 649..909
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 828..900
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 98..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 101665 MW; 3309695114B35B50 CRC64;
MGSQRLWRVL CLITVFCQMG MSSKYGCLFE KKLCPRDQSC SDDGLFGQCR LPQQERIQYE
VSVTVLHKLQ EVLKDLMMQG LSWQDDITQY IIGKELSRVP QTHPPSGRHD NPSSQSAETV
QNAPPSEMRY SPSYRAKGEG DNLNPDLMQR YLDYMIMDPP RSSQSLHMQT LDPYSYRQQY
GYQDNEERSL NSLEGGGFPH TSSHSVGKGS RTQDRDRQVL QDLVSLYLSS PTQPVSPNRG
AAAPLSTSPF YQELDFPLDY TEDYISQQDV EVRKQHEQTE KKTQKDYGSL AGLDDGSLQK
LALLLDHYGI DMKDLTPQQL DNLPAALKQL QMESAAVGTN TAERYRSSAA SRKKITEGAM
THKVDKASIS LPEQPPVPQA SPDNTPAAGA PPSAEGASGK EPRPTALVKT EKQRKKGTAD
GKAQVQEEYG YIVTNQSVVG PALTFRVRPN SQNLSADGVA DKAVAEKNFL ESETDLKILQ
TGVGERADGL GLPTATRIQD GSRWVFMTMV VMACVGGILV ATMTVACLRR HANRLASEKL
GLGPEGGSVT HQEYQDLCRQ HMASKGTGSV GGSGGAAVGS GAGRGGGGTD TSRVSSVSSQ
FSDAPQPSPS SHSSTPSWCE EPAQSNMDIS TGHMILAYME DHLKNKDRLL KEWEALCSYQ
AEPSTVSVAQ SESNLKKNRC PDSVPYDHSR VKMKAEMNPS RTDYINASTI IEHDPRMPAY
IATQGPLSHT ISDFWQMVWE NGCTVIVMMT ALVEDGEKQC DRYWPDEGSS LYHIYEVNLV
SEHIWCNDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAQGI PSSTRTLLDF RRKVNKCYRG
RSCPIIVHCS DGTGRTGTYI LIDMVLNHMA KGVKEIDIAA TLEHVRDQRP GMVRTKDQFE
FALTAVAEEV NAILKALPQ
//