ID A0A3P8ZCF8_ESOLU Unreviewed; 497 AA.
AC A0A3P8ZCF8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons 2 {ECO:0000313|Ensembl:ENSELUP00000026128.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000026128.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000026128.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000026128.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR RefSeq; XP_010885711.1; XM_010887409.3.
DR RefSeq; XP_019898459.1; XM_020042900.1.
DR AlphaFoldDB; A0A3P8ZCF8; -.
DR STRING; 8010.ENSELUP00000026128; -.
DR Ensembl; ENSELUT00000019308.2; ENSELUP00000026128.1; ENSELUG00000001905.2.
DR GeneID; 105020410; -.
DR KEGG; els:105020410; -.
DR GeneTree; ENSGT00950000182973; -.
DR InParanoid; A0A3P8ZCF8; -.
DR OMA; PDSLGWC; -.
DR OrthoDB; 9421at2759; -.
DR Proteomes; UP000265140; LG23.
DR Bgee; ENSELUG00000001905; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF14; PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 2; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..280
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 437..497
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 165..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 57302 MW; 038AA70EDF217147 CRC64;
MSGSYDDSMT DVSSDSFWEV GNYKRTVKRV DDGNRLCNEL MNCFHERARI EKAYAQQLTE
WSKRWRQLIE KGPQYGTLER AWGAMCTEAE KVSELHMEVK AALMAEDFEK LKVWQRDSYH
KQMIGGFKET KEADDGFRKA QKPWAKKLKE METLKKAYHG ACKEEKLATS RENTSKLENN
NPEAQKKLQD KVEKCQQEVE KTKERYEKSL EELDKMTPQY MENMEQVFEQ WQKFEDKRIR
FFREVLLEVK QHLDLSTNHK FQSVYQTMED TISAADSEED LKWFRSNHGP GMPMNWPQFE
DWSMDLNRTL SRRETKKKPS DGVTLTGMSQ MGDQQGAKNS SSLTVPSSTE PVGSNPFEDD
DEEEIAEPVK EQPTVIVNNN NNRSSPLNVK KVEEVKTASS VEKSQDWSDE EVGVNPFSAE
VANGDGNPFE EERSSPVVSV AVRALYDYEG QEQDELSFKA GEEFTKIGNE DDQGWCKGRL
KDGAVGLYPA NYVEDIQ
//
