ID   A0A3P8ZD12_ESOLU        Unreviewed;      1394 AA.
AC   A0A3P8ZD12;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSELUP00000026661.1};
GN   Name=ARHGEF10 {ECO:0000313|Ensembl:ENSELUP00000026661.1};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000026661.1, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000026661.1, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000026661.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_010877465.1; XM_010879163.3.
DR   Ensembl; ENSELUT00000017956.2; ENSELUP00000026661.1; ENSELUG00000002642.2.
DR   GeneID; 105015770; -.
DR   GeneTree; ENSGT00940000153798; -.
DR   OrthoDB; 2916834at2759; -.
DR   Proteomes; UP000265140; LG15.
DR   Bgee; ENSELUG00000002642; Expressed in spleen and 14 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT   DOMAIN          444..631
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1249..1288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..46
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1249..1284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1394 AA;  152510 MW;  3489090854C7E652 CRC64;
     MPRGTAPSMD TVEDFPPPPP EMLADEVPYA DEEEGEQFEF DDSGDETPEA TQPAPAPPAP
     DYGVQAQVNG VSPHLEGKAS NPDPPAAATQ GAAAVPADTT DTAALASDRD LPPPPPPQNS
     APAGPGVVTA DQDVSGDSPP PAGPRTTSQK KVNPYSVIDI SPLQTDQQPG TAPFSSSPVE
     RAVGEGEEEA ESGGQDVPSS SPPCVPPGYS VPVPCGYATP SGVPLITPAY TTPVIIRHFS
     VDEDVTVVGT GSMSADSVFT EEYPSIREED ALSKWVSDPA NTAWMENPDE VIYDDVPREN
     SDSTTEPDEM IYDDVEFGEE GCGSSLDNGW SSSEFESYDE QSDGEGRGEN GLPDAFMRGK
     PPQRKTHMQK LVKAARDGTK DGLEKTKAVV KKGRSFIKTK SFCNERKSTC FEDEESELFI
     EVECLNMEPV LSPIPEGLSQ QQVLRRCILG SILESEKNYL DALKRILEHY EKPLSEIEPR
     LLSDRKLKMT FYRIREILQC HALFQIALAS RVAEWDSLEM IGDVFVASFS KSMVMDAYCE
     YVNNFSTAMA VVRKTCASKP SFLDFLKHRQ ETSSDRVTLY GLMMKPIQRF PQFILLLQDM
     LKNTPAGHSD RLPLQMALTE LETLADKLNE KKREADQRCE IRHIAKAMNE RYLNKLLSNG
     SRYLIRSDDM VETVYNERGE VIKTKERRLF LLNDVLMCAT PNVRCSVEGS GNPPLGHKFL
     LKWSVPLSFV NVVEFGSSEE MADNSRFNPQ PHSGEKVVIN AKPNKLYMGP GQLYQDLQNL
     IHDLSLVNQI SSMIGSLKGN YQNVNPTVAQ DWVSGLQRLI LKKEEEIRAA DRCRIQLQLP
     GKQDKSNRPT YFTAVFNTFS PAIKQSWISN LQMAKLALEE DNLQGWAFAE DDGNQIKKQK
     HPLLLRQMPV VMSKLQEFKV ECAVHNPEPH INTESTADMP ALGHGCVWVA SCTNQMGQVA
     IVALQNSSPK VTECFNVESR ILCMAHVPID QRTLENEERD PESSISLVGK ASDTPTVCLG
     MEEGSIIVYK SSQRSKKVRL QHFFTPDKST VTSLVHKRQF LYAGLVSGSV AIFSRAQDGL
     WSPDSPKVLK LGVLPVKAMI AVEDHIWASS GGQVFIISTA THTVERQLEA HQEEGMVVSH
     MVVAGVGIWI AFSSGSTLRL FHTETLEHLQ DINTATPVHN TLAGNQRVSV SSLLVCHGLL
     LVGTNLGVTV ALSVPRLQGI PKVTGRGMVS FHAHHGPVKF LTMATAVCNR PSGTSPPSQP
     GDTQDGETAQ ASPPPTTGSM PTSALAPGQG RGVWLGEAGC TSMALQDSLS SSCGSLALSQ
     GSLEHGPEDG AIYDLVNDPA HHQRGRRVQK VDISSLLVVS GGLGHRRVNK KTKQSRHEET
     MSTIMVWQIP LLNM
//