ID A0A3P8ZDL7_ESOLU Unreviewed; 222 AA.
AC A0A3P8ZDL7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Kit ligand {ECO:0000256|ARBA:ARBA00017304};
DE AltName: Full=Mast cell growth factor {ECO:0000256|ARBA:ARBA00030364};
DE AltName: Full=Stem cell factor {ECO:0000256|ARBA:ARBA00033123};
DE AltName: Full=c-Kit ligand {ECO:0000256|ARBA:ARBA00032898};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000026861.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000026861.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000026861.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell
CC projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm,
CC cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the SCF family. {ECO:0000256|ARBA:ARBA00010419}.
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DR AlphaFoldDB; A0A3P8ZDL7; -.
DR STRING; 8010.ENSELUP00000026861; -.
DR Ensembl; ENSELUT00000017440.2; ENSELUP00000026861.2; ENSELUG00000002894.2.
DR GeneTree; ENSGT00390000018272; -.
DR InParanoid; A0A3P8ZDL7; -.
DR OMA; CHYQEQS; -.
DR OrthoDB; 3991511at2759; -.
DR Proteomes; UP000265140; LG23.
DR Bgee; ENSELUG00000002894; Expressed in head kidney and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005173; F:stem cell factor receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003452; SCF.
DR PANTHER; PTHR11574; KIT LIGAND; 1.
DR PANTHER; PTHR11574:SF0; KIT LIGAND; 1.
DR Pfam; PF02404; SCF; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..222
FT /note="Kit ligand"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028399670"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 222 AA; 25045 MW; 8592A400EA3DB5D4 CRC64;
MPSLNRSRVQ IRTTTCVILF LLTSFGICSG GFGNPVTDDN LPILIFLQKN NIPKDYKIPI
NHIPKNMSGV CWFLLNIYPL EQSLRELAQV FGAISSNKDN IMLFITMLQN LRFKFDHEEL
EVTMQMFKCH YREVKWPTGQ YFDYVRAILN SAGKGKGGFR CAPPPCPAPS SAPGKKQSTK
CRGVNNWSEA QDHDQTRSRG SLLCLLLIPV TACVFLIVWV VS
//
