ID A0A3P8ZEH8_ESOLU Unreviewed; 417 AA.
AC A0A3P8ZEH8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=COP9 signalosome complex subunit 4 {ECO:0000256|ARBA:ARBA00014881};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000027234.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000027234.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000027234.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle {ECO:0000256|ARBA:ARBA00004234}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the CSN4 family.
CC {ECO:0000256|ARBA:ARBA00010417}.
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DR AlphaFoldDB; A0A3P8ZEH8; -.
DR Ensembl; ENSELUT00000016467.2; ENSELUP00000027234.2; ENSELUG00000003391.2.
DR GeneTree; ENSGT00940000153510; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000003391; Expressed in camera-type eye and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008021; C:synaptic vesicle; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041406; CSN4_HTH.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR10855:SF2; COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR Pfam; PF18420; CSN4_RPN5_eIF3a; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 197..377
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 417 AA; 47537 MW; 8439D346B0A4570D CRC64;
MATGVRQELA QLMNSSGSHK DLAGKYRQIL EKAIQFTDAE QLESLKAFVE AMVNENVSLV
ISRQLLTDFC TNIPSLPDST AKAVYHFTLE KIQPRVISFE EQVASIRQHL ATIYEKEEDW
RNAAQVLVGI PLETGQKQYN VDYKLDTYLK IARLYLEDDD PVQAEAYINR ASLLQNESTN
EQLQIHYKVC YARVLDYRRK FIEAAQRYNE LSYKSIVHET ERLEALKHAL HCTILASAGQ
QRSRMLATLF KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADAQLHD
CGFLFPGSSI LDRAVIEHNL LSASKLYNNI TFEELGALLE IPPAKAEKIA SQMITEGRMN
GFIDQIDGIV HFETREPLPT WDKQIQSLCF QVNNLLEKIT AAAPEWTAQA MEAQMTQ
//
