ID A0A3P8ZEW1_ESOLU Unreviewed; 618 AA.
AC A0A3P8ZEW1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Formin binding protein 1b {ECO:0000313|Ensembl:ENSELUP00000027235.2};
GN Name=FNBP1 {ECO:0000313|Ensembl:ENSELUP00000027235.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000027235.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000027235.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000027235.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
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DR AlphaFoldDB; A0A3P8ZEW1; -.
DR Ensembl; ENSELUT00000016453.2; ENSELUP00000027235.2; ENSELUG00000003481.2.
DR GeneTree; ENSGT00950000183047; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000003481; Expressed in head kidney and 15 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd11629; HR1_FBP17; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR PANTHER; PTHR15735:SF13; FORMIN-BINDING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 9..285
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 398..475
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 551..612
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 278..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 71092 MW; 1CB325068484E1D6 CRC64;
MVGPWLVFQR WDNGVLACRR LNAMLPLRRD QFDNLEKHTQ SGIEFVERYT KFVKERTEIE
ISYAKQIRNL SKKYQPKKNS REEEENKYTS CRAFLSTLNE LNDYAGQHEV IAENLSSQII
AELSRYLTEL KAERKSHFQD GRKAQQHMES SWKQLESSKR RFERDCKEAD RAQQYFEKMD
NDINVTKADV EKARQQAQMR HQMAADSKTE YSNFLTKFNQ EQNEHYYTVI PSIFQKLQEM
EERRIERVGM SMKTYADVDR DVLPIVGKCL DGMTKAAESI EPKTDSKQVV DSYKSGFEPP
GDLEFEDYGP GQAMKRTVSE TSLSNSRGEG KERPSGGKSK GKLWPFIKNK NKSPKQSKEP
ISNRFNEFMA SKPKMTCLRS LRRGLSLKLG SGPEDFSHLP PEQRRKKLQA KIDDLNKDIQ
KEMDQKDALT KMKGVYEKNP QMGDPASVDP RLAEIAQNIE KLQFEVQKFE GWLAEVEGRL
PSKSDPPRRQ SGLYETQNSN SSTVGNNCAQ DRESPDGSYT EEQSSETQAK VTISNPPEVD
DEFDDDEETL PTIGTCKAIY PFEGHNEGTI SVTEGELLYV IEEDKGDGWT RVRRNEDEEG
YVPTSYVEVF LETNAKDS
//
