ID A0A3P8ZFG1_ESOLU Unreviewed; 1517 AA.
AC A0A3P8ZFG1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Calmodulin regulated spectrin associated protein 1 {ECO:0000313|Ensembl:ENSELUP00000027022.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000027022.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000027022.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000027022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR Ensembl; ENSELUT00000017010.2; ENSELUP00000027022.1; ENSELUG00000003150.2.
DR GeneTree; ENSGT00950000182975; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000003150; Expressed in camera-type eye and 15 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 148..263
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1380..1514
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 340..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 787..817
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 353..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1146..1161
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1283
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1517 AA; 166656 MW; C535239B4FE97B10 CRC64;
MFLTGNVSPL FVRMDLDLCA GGDSTRRKLD TAGEGAVEVV PLEMYDSARA KIDANLRWLF
AKAYGIDHIP EDLRDPFYTD QYEQEHIKPP VLHLLLSCEL YCRVCALILK TDQAASLQSH
MSVIQALSRK GIYVMESDDV PVTDADLACV PIKMVRYRRE HNTGRQLPFF PVLEDLMRDV
CDGAALLTVV HYYCPDLMKL DDICLKEVTS IADSLYNIQL LKEFANEYLN KSFYLTMEDM
LYSPLVLKHN VMVFIAELFW WFETVKPEFV QPRTDEFKDA RAMAQPKSAR PSVPISNATK
RSFQVTPGMA EASLSVSAQS SPDVCNRYFL HPAEDCDPLK GGPAASFSPS HPLLPLRQRQ
QKQQGEDGSG IRNRSNSLEN RQPRASVQAW PDKRQRPMST LNPYTFGISA TDSDADIASG
DSVSLARSIS KDSLASNVAN LTPKHQSLTP QGHTLIGPAQ GVRPQVASAP QRVNGHGLLG
NVDLEEEEEL EAVMRTEASP ALNNPLEARP AGAMPKDSFY LEPLMPAVLK PAKEKSVCLN
KEEESGEAGR SRGAGSLRRA EGGPALATSA RRKTPNSLNR TYTPTSSGEL DMSTEAWLAG
PPQGQGSFKP LVTSSAEPPG GFYLHSDSED QKPGHELDLD EADEEDLDEA LTTKDPTRAR
KSFEDEEEEE ESAKLQEDQK VKEKEDKDKG DDGASGRSSP CLSTHSQASS LASGSVRMTS
FAERKAQQRF GSNQDLRTSA SSSQRTTPDG SECSGPLSLP TSWRLKRDQS PCSPQGGRGD
GGNNVLASEL VQLHMQLEEK RKAIEHQKKK MEVLSARQRQ KLGKAAFLHI VKKGKSDTLP
HLLKPDHYSK EELNGDKGGS SKDDSCVDML RAAKETDSSA SPVPGAFEAV DRKGSRSPGP
LLDEELDLNE CNRSIDMLND AIGSIQQQMM QLSLQQEQLM KQNVQSPPGV LSPSLTNDKP
AVSEPKARAA VHFVEIGSGT PATGTAPTRK PPKLTSARGP RSKPSELKLA KEHGRQGLAS
SRAITPTHSL ETLPHLRQFP GGRSPRADQP DASPRTPPAI GETNSGQDKP GRSATFRLHD
ESNLRAVARN EPVTITTPEV SFDECLSSTP REGELNSSDG SGKENVPSEE VSRSKAPLIE
VDLSDLKDPE ELEGEGQEST IEGDDGELKS GLGFFFKDEQ KAEDELAKKR AAFLVRQQKK
AEEARLRKLQ LEAESEQKRE EARQKAEEDR MRKEEEKARR ELIKEQYLRR KQQELMEEQG
LGSPAKPKTP KTKPKKAVHQ THRPKSAFSR EESSSDTFSS KCSSSTPDNL SSAQSGSSLS
LASAATTEPD SVNSGGAGSQ RGESVESFPG LSRNASRNTE RDWDNGSTAS SITSMAEYTG
PKLFKEPSSK SNKPIIFNAI THCCLAGKVN EAQKNTLLEE LEKVEAHHLM ILFRDGGCQF
RGVYSYFPDT EEILKLTGTG PKSISKKMID KLYKYSSDRK QFTVIPAKTV SVSIDAITIH
NHLWQAKRTT MPKKAGK
//
