ID A0A3P8ZFI9_ESOLU Unreviewed; 1281 AA.
AC A0A3P8ZFI9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Si:dkey-21e5.1 {ECO:0000313|Ensembl:ENSELUP00000027203.1};
GN Name=KCNT1 {ECO:0000313|Ensembl:ENSELUP00000027203.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000027203.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000027203.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000027203.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8010.ENSELUP00000027203; -.
DR Ensembl; ENSELUT00000016556.2; ENSELUP00000027203.1; ENSELUG00000003400.2.
DR GeneTree; ENSGT00940000156880; -.
DR InParanoid; A0A3P8ZFI9; -.
DR OMA; WADRYLL; -.
DR Proteomes; UP000265140; LG13.
DR Bgee; ENSELUG00000003400; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF14; POTASSIUM CHANNEL SUBFAMILY T MEMBER 1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 190..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 294..363
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 520..614
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1073..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1246..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1281 AA; 145395 MW; 63080F657C51D14E CRC64;
MMGPRTPTEP EATMSPLRRS SSSPGDRSSS TETLQKNNSS NTGVILDISA LKMADVDSEV
PPLPPRYRFR DLLLGDQSFQ NDDRCQEEYS MDSTNAQVQV EFYVNENTFK ERLKLFFIKN
QRSSLRIRLF NLSLKLLTCA LYVLRVSLDY PEQVTDICVT CPNRTSPAAA ESTEITEINW
DLIFWVNRKV PVWAIQVTVA LISFLEAMLL TYLSYKGNIW EQIFQISFIL EMINTVPFII
TIFWPPLRNI FIPVFLNCWL AKCALENMIN DLHRAIQRTH SAMFNQVLIL ICTLLCLVFT
GACGIQHLER AGKNLTLFNS LYFCIVTFST VGYGDVTPHI WPSQLLVVIL ICVALVVLPL
QFEELAYLWM ERQKSGGNYS RHRAQTEKHA VLCVSSLKID LLMDFLNEFY AHPRLQDYYV
VILCPTEMDI QVRRILQIPL WSQRVIYLQG SALKDTDLMR AKMDDAEACF ILSSRNEVDR
TAADHQTILR AWAVKDFAPN CPLYVQILKP ENKFHVKFAD HVVCEEEFKY AMLALNCVCP
ATSTLVTLLV HTSRGQEGQL SPEQWQRTYG RCSGNEVYHI RLGDSKFFGE YDGKSFTYAS
FHAHKKYGVC LIGVKREDNK SILLNPGPRH IMAAPDTCYY INITKEENSA FIFKQEEKDK
KGLPVAGLYD APSRLPVHSI IASMGTVAMD LQNPADPPED SSKLSLPTEN GAGSRRPSIG
PVLEIADSSS ILPCDLLSDQ SEDETSQSEE EGSSVSDFVK GYPPNSPYIG SSPTLCHLLP
QKASFCCLRL DKKCNHNSFE DAKAYGFKNK LIIVSAETAG NGLYNFIVPL RAYYRPRKEL
NPIVLLLDYP PDNHFLEAIC CFPMVYFMAG TIDNLDNLLQ CGIIYADNLV VVDKESTMSA
EEDYMADAKT IVNVQTMFRL FPSLSIITEL THPSNMRFMQ FRAKDCYSLA LSKLEKIERD
KGSNLAFMFR LPFAAGRVFS ISMLDTLLYQ SFVKDYMIPI ARLLLGLDTT PGSGYLCAMK
VTEEDLWIRT YGRLFQKLCS SSAEIPIGIY RTESHMFSSS EIKASYKQSQ VSINVDDPVG
DEPRDSRREP WKKTAHRNST ASDQSEHPLL RKKSLQWARR LSRKNTKPPT RTERISQQRL
NLYRRSERQE LSELVKNRMK HLGLPTVGYE DVANLTASDV MNRVNLGYLQ ELQGISEHPI
SEETRTGANT DEMNDHQNTL SYVLINPPPD TMLELNDIVY IIRSDPLAGP DVPEDPAQGQ
SSSGRRMRQD FGTETRDETH L
//
