ID A0A3P8ZFW4_ESOLU Unreviewed; 566 AA.
AC A0A3P8ZFW4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=DENN domain-containing protein 2D-like {ECO:0000313|Ensembl:ENSELUP00000027177.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000027177.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000027177.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000027177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P8ZFW4; -.
DR Ensembl; ENSELUT00000016613.2; ENSELUP00000027177.1; ENSELUG00000003334.2.
DR GeneTree; ENSGT00950000182931; -.
DR Proteomes; UP000265140; LG12.
DR Bgee; ENSELUG00000003334; Expressed in stomach and 14 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF2; DENN DOMAIN-CONTAINING PROTEIN 2D; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 170..543
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 64916 MW; 24909943876B6A94 CRC64;
MEREKDHRRR WSFSSFRIKR KEPADDRETG YRRRGLLSYS SVRESSRKDS IQEETEGVAA
PVTGASAGPT HLVQLKPMTD RLKGEQPQGA AYGQEKDAAS CDLRTVHSRE SEQSGRGATK
RLSTMWSSIW GKSHQDHVMK GPALHESLEP AVVDSSAREQ RYMSGQYFFE YLVVVSLKKS
KEGAYEPQIT YQFPKRDGMV KFQREEEEKT LKALTLFCFP EGINWAPLTE YHSETFSFVL
TELDASRRNG YCRRLLPGGN GARPPEAYCI ISKLACFGLF SKIFDEVEKR RQISMAMIYP
FMQSLREAAF PAPGNTVKIK SFIPDKGTEI ISLTRPLDSW LEHVDFRTLF RCLTDEEVLL
VFAATVMERR IVFIAEELST LSQVIHAVAA LLYPFIWQHT FISIVPEILI DVVMAPTPFL
LGVQRRLLDQ VIDQSDCGDE KSILPPKLHD EILQSLRHRK DNASVEQLNK VVSEAFLLFF
VKTVGHFASY VKRNDRGEPG VFQSRSFYKA IESKTTRHFV KKFLQTQMFD LFIQDVEQQP
TSSQKGIFHQ KVVEYQKKKA DAKKKH
//
