ID A0A3P8ZGL5_ESOLU Unreviewed; 546 AA.
AC A0A3P8ZGL5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=EH domain-containing protein 4-like {ECO:0000313|Ensembl:ENSELUP00000027969.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000027969.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000027969.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000027969.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_010891224.1; XM_010892922.3.
DR AlphaFoldDB; A0A3P8ZGL5; -.
DR STRING; 8010.ENSELUP00000027969; -.
DR Ensembl; ENSELUT00000014579.2; ENSELUP00000027969.1; ENSELUG00000004390.2.
DR GeneID; 105023592; -.
DR KEGG; els:105023592; -.
DR GeneTree; ENSGT00940000158601; -.
DR InParanoid; A0A3P8ZGL5; -.
DR OMA; ISAKKEM; -.
DR OrthoDB; 12127at2759; -.
DR Proteomes; UP000265140; LG15.
DR Bgee; ENSELUG00000004390; Expressed in spleen and 14 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd00052; EH; 1.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR040990; DUF5600.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR031692; EHD_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11216; EH DOMAIN; 1.
DR PANTHER; PTHR11216:SF161; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE CLONE 15, ISOFORM A; 1.
DR Pfam; PF18150; DUF5600; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF12763; EF-hand_4; 1.
DR Pfam; PF16880; EHD_N; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 56..287
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 445..533
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 477..512
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 546 AA; 62157 MW; 74CFAE519DC06310 CRC64;
MFSWVNKEQG GRNKDGEMYQ TVTEGLQQLY TKKLLPLEET YLFHDFHSPA LEAADFQSKP
MVLLVGQYST GKTTFIRYLL EQDFPGMRIG PEPTTDGFIA VMYGENEGVV PGNALVVDPK
KPFRKLNAFG NSFLNRFICS QMPNQVLQGI SIIDTPGILS GEKQRISRGY DFSEVLRWFG
ERVDRIILLF DAHKLDISDE FSEAIKAFRG QDDKIRVVLN KADQVDTQQL MRVYGALMWS
LGKVINTPEV ARVYLGSFWA KPLQNTDNRR LFEAETQDLF KDIQGLPRNA ALRKLNDLIK
RARLAKVHAY IISYLKREMP SLFGKEKKKE ELIMRLPEIY TILQREHHIS PGDFPNAVKM
QEQLQHYDFS RFPSLKIKLI ESVDKMLANK ISGLMTMIRD EESKAPPAMV SGGAFEGSQD
GPFGQGYGEG ISAGSDCEDW IVSRDKHKYD EIFYSLNPIN GKITGVNAKK EMMSSRLPNT
VLGKIWKLAD CDKDGMLDDE EFALAQHLIK VKLEGYELPT ELPRHLVPPA HRKSEVAEIL
YNNDID
//
