ID A0A3P8ZGY7_ESOLU Unreviewed; 412 AA.
AC A0A3P8ZGY7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Interferon-inducible GTPase 5 {ECO:0000313|Ensembl:ENSELUP00000002521.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000002521.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000002521.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000002521.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. IRG family. {ECO:0000256|ARBA:ARBA00005429}.
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DR AlphaFoldDB; A0A3P8ZGY7; -.
DR Ensembl; ENSELUT00000015579.2; ENSELUP00000002521.2; ENSELUG00000003864.2.
DR GeneTree; ENSGT00950000183007; -.
DR OMA; MFIEYLA; -.
DR Proteomes; UP000265140; LG16.
DR Bgee; ENSELUG00000003864; Expressed in nose and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0098542; P:defense response to other organism; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030385; G_IRG_dom.
DR InterPro; IPR007743; Immunity-related_GTPase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR32341; INTERFERON-INDUCIBLE GTPASE; 1.
DR PANTHER; PTHR32341:SF10; INTERFERON-INDUCIBLE GTPASE 5; 1.
DR Pfam; PF05049; IIGP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51716; G_IRG; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140}.
FT DOMAIN 57..238
FT /note="IRG-type G"
FT /evidence="ECO:0000259|PROSITE:PS51716"
SQ SEQUENCE 412 AA; 46565 MW; 807700B1FDCCC470 CRC64;
MVDNTDPFWP QPDSELDIIT EDEITTIRRE VEEALENESL TSAAGKIQDY LEDVQNVELN
IAITGESGSG KSTFINAFRG LDDEAKDSAA TGVVETTMEV KDYPHPKHPN VKLWDLPGVG
TPNFKPEDYL KKVEFDRYDF FIIISSERFR ANDVLLAKEI QKIKKKFYFV RSKIDATMDA
EKRRKKNFNQ DETLERIRLN CIKGLEDQDL GCPKVFLISS FELHLYDFPD LEETMEKELP
AHKRQTLLMS IPNLTLEINQ RKKEALLSRV WRSALKSGLA ATVPIPGLSF AADVKILTDE
IYKYYHAFGL DDESLHNLAE RMDVTEKELK SVIKSPLLSQ VKHDLIVKML TKAAGGGLMI
AEYWASTIPV IGSMAAGALS FGTTQYMLKS CLNELSEDAK NVLMKALKAD NE
//
