ID A0A3P8ZHM4_ESOLU Unreviewed; 759 AA.
AC A0A3P8ZHM4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Exostosin-1c {ECO:0000313|Ensembl:ENSELUP00000028329.1};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000028329.1, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000028329.1, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000028329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC {ECO:0000256|ARBA:ARBA00010271}.
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DR RefSeq; XP_012991126.1; XM_013135672.2.
DR RefSeq; XP_012991128.1; XM_013135674.2.
DR RefSeq; XP_012991130.1; XM_013135676.2.
DR RefSeq; XP_012991131.1; XM_013135677.2.
DR RefSeq; XP_019906019.1; XM_020050460.1.
DR RefSeq; XP_019906020.1; XM_020050461.1.
DR RefSeq; XP_019906021.1; XM_020050462.1.
DR RefSeq; XP_019906022.1; XM_020050463.1.
DR AlphaFoldDB; A0A3P8ZHM4; -.
DR STRING; 8010.ENSELUP00000028351; -.
DR Ensembl; ENSELUT00000013656.2; ENSELUP00000028329.1; ENSELUG00000004910.2.
DR GeneID; 105005807; -.
DR KEGG; els:105005807; -.
DR GeneTree; ENSGT00940000163960; -.
DR InParanoid; A0A3P8ZHM4; -.
DR OMA; RNRYMWN; -.
DR OrthoDB; 1220028at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000004910; Expressed in brain and 12 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR InterPro; IPR004263; Exostosin.
DR InterPro; IPR040911; Exostosin_GT47.
DR InterPro; IPR015338; GT64.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR Pfam; PF03016; Exostosin; 1.
DR Pfam; PF09258; Glyco_transf_64; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 107..390
FT /note="Exostosin GT47"
FT /evidence="ECO:0000259|Pfam:PF03016"
FT DOMAIN 475..742
FT /note="Glycosyl transferase 64"
FT /evidence="ECO:0000259|Pfam:PF09258"
SQ SEQUENCE 759 AA; 87811 MW; FE8AF0ECEE1AC2AE CRC64;
MQARKKYVLL GLCACCWLLL FYWGGGVQLR LLKLLGRQRG EVVRPWPDWT DRALLPGYAQ
LEELQTGPGS AESPRQRRQA WTSIYKDSRC RMETCFDFTR CRRRGRDGFR VYVYPSEKGE
RVSESYRKIL TSIGESRYST TDPREACLFV LGIDTLDRDQ LSGQFVPNLD DRIKGYPLWN
EGRNHLIFNL YSGTWPNYTE DLGFNIGQAI LAKASLNTEH FRPGFDVSIP LFSKEHPQKG
GERGWLVRNT VPPRRKYLLM FKGKRYLTGI GSDTRNALHH IHNGKDIVSL TTCRHGKDWE
KHKDARCDHD NLEYERFDYQ ELLHNSTFCL VPRGRRLGSF RFLESLQAAC IPVLLSNGWE
LPFSDVIQWN QAVIEGDERL LLQVPSTVRA VGNERVMALR QRTQMLWEAY FSSVDKIVLT
TLEIIKDRVF SHISRNKYMW NALPGGLLVL PEYSTHLAHF PFYYLSLGVS PGQEFTAIIH
AVSPLVSQSQ PIMKLLQVVS KSKYCSQIII LWNSEKPPPY RSKWPPMPVP LTVTDGRRKT
SSRFLPNVAI ETEAVLSLDE DTVLLTSEVN FAFLVWRSFP ERIVGYPPRS HFWDPVKQAW
GYTSKWTNEY SIVLTGAAFY HRYYHYLFSH YLPPSLRALV DRTSNCEDIL MNFLVSSVTH
LPPIKVAQRK QYKELPSPQV RPHPSMVNLT NELPSPQGTK ISAPWANPEH FSQRQECVNS
FASWFGYMPL VHSQFRLDPV LFKDQVSVLR KKYKDLERA
//
