ID A0A3P8ZIQ2_ESOLU Unreviewed; 1037 AA.
AC A0A3P8ZIQ2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Integrin subunit alpha 2 {ECO:0000313|Ensembl:ENSELUP00000028606.2};
GN Name=ITGA2 {ECO:0000313|Ensembl:ENSELUP00000028606.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000028606.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000028606.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000028606.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3P8ZIQ2; -.
DR Ensembl; ENSELUT00000012959.2; ENSELUP00000028606.2; ENSELUG00000005341.2.
DR GeneTree; ENSGT00940000156303; -.
DR Proteomes; UP000265140; LG14.
DR Bgee; ENSELUG00000005341; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 26..1037
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5028513245"
FT TRANSMEM 972..991
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1003..1024
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 32..90
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 128..315
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 321..374
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 429..493
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 494..552
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 556..616
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1037 AA; 113675 MW; 5B96C7C117AC2DDF CRC64;
TGFLWLAAAP TCLLLIPVIS TCCQSLSFNV GTAGAKVFSG PATEEFGYTV HQFKNHLGKW
LLVGSPWSGY KQDRKGDLYK CEITGSTSNC QRLNLQYYYP GICAEVSPLF KPLPAFSPAL
QTCGGPMDVA IVLDGSNSIY PWPPVVDFLK KLLENLDIGP DNTQVTIIQY GVDPFIEFHL
NAHKTKQSMI TAAAKIPQRQ GLETNTFRAI EFARKQAFLP ENGARPGASK VMVVVTDGES
HDKNLRDDVI RKCETDRITR FGIAVLGYYI RNDIDTKNLV DEIKSIASTP TDRYFFNVSA
EEALLEIAGS LGDRIFNIEG TGKGDGDFQM EMSQVGFSAH QTKKQNMIML GAVGAYSWSG
TVVHYTSQKS DIFPQTAFQT ILQDKNHSSL LGYSVTTLND GTMEYYVAGA PRSNHTGQVI
VYTINAKGQP IVLDSQRGDQ IGSYYGSVLC PLDVDKDGVS DLLLVGAPMF MSEHKKENGK
VYLLTFTKGI LSDQGVLKGP SPAENARFGM SISAVLDLNM DGYSDVVVGA PLEDDNRGVI
YVFNGDKKTL RTEYSQRILG SKLDPLLQYF GRSLDTSSDL NDDTIPDVSV GAYGKVVQLW
SRGVAIVTAS VTFNPDKISI LSKKCVVNGK RTSCFNTEVC FSATFKPKNP VGPLLSGLFC
ESCLQIKNEA PDLVNSIGLR VEIALQDPDS SPVLDVLSPN AWQFFIPFSK ECGSDEVCDS
DLELSVKKGQ MIPSSSKMLI SLKNKRLSFT VSVVNKKENA YNTRVIVKYS KNLFYASITP
PVSFEINFDF NLLERQPIAD VRFEVLSDST EADMSDNHVL LSIPVHYDSE ITVSWKMDPE
FYVIEANHEV KTTVNTFDDI GPEFKFSLKV STGNLPISLA YFTVSMPSTT SRGNPLLYIT
GVTTAPAGDV TCDVTLNPLK ITQQPYTPTF SNENLMSTEI LDCNTAKCQH MKCFLKDMQI
KSAFFVNVTS RIWNGTFAAV SIANIIFGVT ISKPGEKGEV PVGIIVGSVI GGLLLLALAI
GLLWKVSANL FLLLYCC
//