GenomeNet

Database: UniProt
Entry: A0A3P8ZIQ2_ESOLU
LinkDB: A0A3P8ZIQ2_ESOLU
Original site: A0A3P8ZIQ2_ESOLU 
ID   A0A3P8ZIQ2_ESOLU        Unreviewed;      1037 AA.
AC   A0A3P8ZIQ2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Integrin subunit alpha 2 {ECO:0000313|Ensembl:ENSELUP00000028606.2};
GN   Name=ITGA2 {ECO:0000313|Ensembl:ENSELUP00000028606.2};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000028606.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000028606.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000028606.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU003762}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3P8ZIQ2; -.
DR   Ensembl; ENSELUT00000012959.2; ENSELUP00000028606.2; ENSELUG00000005341.2.
DR   GeneTree; ENSGT00940000156303; -.
DR   Proteomes; UP000265140; LG14.
DR   Bgee; ENSELUG00000005341; Expressed in liver and 15 other cell types or tissues.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF20806; Integrin_A_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 5.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           26..1037
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5028513245"
FT   TRANSMEM        972..991
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   TRANSMEM        1003..1024
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          32..90
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          128..315
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          321..374
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          429..493
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          494..552
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          556..616
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1037 AA;  113675 MW;  5B96C7C117AC2DDF CRC64;
     TGFLWLAAAP TCLLLIPVIS TCCQSLSFNV GTAGAKVFSG PATEEFGYTV HQFKNHLGKW
     LLVGSPWSGY KQDRKGDLYK CEITGSTSNC QRLNLQYYYP GICAEVSPLF KPLPAFSPAL
     QTCGGPMDVA IVLDGSNSIY PWPPVVDFLK KLLENLDIGP DNTQVTIIQY GVDPFIEFHL
     NAHKTKQSMI TAAAKIPQRQ GLETNTFRAI EFARKQAFLP ENGARPGASK VMVVVTDGES
     HDKNLRDDVI RKCETDRITR FGIAVLGYYI RNDIDTKNLV DEIKSIASTP TDRYFFNVSA
     EEALLEIAGS LGDRIFNIEG TGKGDGDFQM EMSQVGFSAH QTKKQNMIML GAVGAYSWSG
     TVVHYTSQKS DIFPQTAFQT ILQDKNHSSL LGYSVTTLND GTMEYYVAGA PRSNHTGQVI
     VYTINAKGQP IVLDSQRGDQ IGSYYGSVLC PLDVDKDGVS DLLLVGAPMF MSEHKKENGK
     VYLLTFTKGI LSDQGVLKGP SPAENARFGM SISAVLDLNM DGYSDVVVGA PLEDDNRGVI
     YVFNGDKKTL RTEYSQRILG SKLDPLLQYF GRSLDTSSDL NDDTIPDVSV GAYGKVVQLW
     SRGVAIVTAS VTFNPDKISI LSKKCVVNGK RTSCFNTEVC FSATFKPKNP VGPLLSGLFC
     ESCLQIKNEA PDLVNSIGLR VEIALQDPDS SPVLDVLSPN AWQFFIPFSK ECGSDEVCDS
     DLELSVKKGQ MIPSSSKMLI SLKNKRLSFT VSVVNKKENA YNTRVIVKYS KNLFYASITP
     PVSFEINFDF NLLERQPIAD VRFEVLSDST EADMSDNHVL LSIPVHYDSE ITVSWKMDPE
     FYVIEANHEV KTTVNTFDDI GPEFKFSLKV STGNLPISLA YFTVSMPSTT SRGNPLLYIT
     GVTTAPAGDV TCDVTLNPLK ITQQPYTPTF SNENLMSTEI LDCNTAKCQH MKCFLKDMQI
     KSAFFVNVTS RIWNGTFAAV SIANIIFGVT ISKPGEKGEV PVGIIVGSVI GGLLLLALAI
     GLLWKVSANL FLLLYCC
//
DBGET integrated database retrieval system