ID   A0A3P8ZIR7_ESOLU        Unreviewed;       341 AA.
AC   A0A3P8ZIR7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00012168, ECO:0000256|RuleBase:RU361159};
DE            EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168, ECO:0000256|RuleBase:RU361159};
OS   Esox lucius (Northern pike).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC   Esocidae; Esox.
OX   NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000028560.2, ECO:0000313|Proteomes:UP000265140};
RN   [1] {ECO:0000313|Ensembl:ENSELUP00000028560.2, ECO:0000313|Proteomes:UP000265140}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25069045;
RA   Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA   von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT   "The genome and linkage map of the northern pike (Esox lucius): conserved
RT   synteny revealed between the salmonid sister group and the Neoteleostei.";
RL   PLoS ONE 9:e102089-e102089(2014).
RN   [2] {ECO:0000313|Ensembl:ENSELUP00000028560.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:46911; EC=3.5.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000227,
CC         ECO:0000256|RuleBase:RU361159};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU361159};
CC       Note=Binds 2 manganese ions per subunit.
CC       {ECO:0000256|RuleBase:RU361159};
CC   -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC       arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098,
CC       ECO:0000256|RuleBase:RU361159}.
CC   -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00742, ECO:0000256|RuleBase:RU003684}.
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DR   AlphaFoldDB; A0A3P8ZIR7; -.
DR   STRING; 8010.ENSELUP00000028560; -.
DR   Ensembl; ENSELUT00000013063.2; ENSELUP00000028560.2; ENSELUG00000005202.2.
DR   GeneTree; ENSGT00950000183195; -.
DR   InParanoid; A0A3P8ZIR7; -.
DR   OMA; YAMDSID; -.
DR   OrthoDB; 161483at2759; -.
DR   UniPathway; UPA00158; UER00270.
DR   Proteomes; UP000265140; LG05.
DR   Bgee; ENSELUG00000005202; Expressed in liver and 14 other cell types or tissues.
DR   GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd09989; Arginase; 1.
DR   Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR   InterPro; IPR014033; Arginase.
DR   InterPro; IPR006035; Ureohydrolase.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR   NCBIfam; TIGR01229; rocF_arginase; 1.
DR   PANTHER; PTHR43782; ARGINASE; 1.
DR   PANTHER; PTHR43782:SF2; ARGINASE-1; 1.
DR   Pfam; PF00491; Arginase; 1.
DR   PIRSF; PIRSF036979; Arginase; 1.
DR   PRINTS; PR00116; ARGINASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR   PROSITE; PS01053; ARGINASE_1; 1.
DR   PROSITE; PS51409; ARGINASE_2; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism {ECO:0000256|ARBA:ARBA00022503,
KW   ECO:0000256|RuleBase:RU361159};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003684};
KW   Manganese {ECO:0000256|RuleBase:RU361159};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW   Urea cycle {ECO:0000256|ARBA:ARBA00022436, ECO:0000256|RuleBase:RU361159}.
SQ   SEQUENCE   341 AA;  36674 MW;  0CF29FE11312A049 CRC64;
     PDTIMVIMKS SRGLQIAFGI YKRSHHSVGI IGAPFSKGQP RDGVEKGPDL IRAAGLVEKL
     KAQGCAVKDY GNLTFEEVAN DEPVGRVKRP RAVGSANKRL SAAVHAVKSD GHTCVMLGGD
     HSLAIGSILG HAASKAELSV VWVDAHADIN TPLTSPTGNI HGQPMSYLIH ELQSKIPVLP
     NFSWIKPCVS AKDIVYIGLR DVDPEEHYIL KSLGIKAFSM SEVDRLGIAK VMEQTGDYIF
     SKVKKPIHLS YDIDALDPSI TPATGTPVVG GLTYREGIYI TETICQTGLL SAVDLVEVNP
     KRGRTEDEIS STVSAAVDLI QGCFGKLREG NHSSDYKMPL P
//