ID A0A3P8ZKW2_ESOLU Unreviewed; 499 AA.
AC A0A3P8ZKW2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Insulin-like growth factor 2 mRNA binding protein 3 {ECO:0000313|Ensembl:ENSELUP00000029088.2};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000029088.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000029088.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000029088.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
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DR AlphaFoldDB; A0A3P8ZKW2; -.
DR Ensembl; ENSELUT00000011735.2; ENSELUP00000029088.2; ENSELUG00000005947.2.
DR GeneTree; ENSGT00940000154957; -.
DR Proteomes; UP000265140; LG10.
DR Bgee; ENSELUG00000005947; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF158; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 4.
DR SMART; SM00322; KH; 4.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 4.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..75
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 145..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 54656 MW; D6AD2B3E1B997313 CRC64;
MNKLYIGNVS EEASAEDLET IFEQWKIPHS GPFLVKTGYA FVDCPDEKVA MKAIDILSGK
VELHGKLLEV EHSVPKRQRS CKLQIRNIPP HMQWEVSGIC SIGKPLGGSV LLSFCVVARA
MEKLNGFLME NFALKVSYIP DETVTTDAPP LGGGRRGFAP RGPPRSGSPG LGARPKLQSD
VPLRILVPTQ FVGAIIGKEG ATIRNITKQT HSKIDIHRKE NAGAAEKPIT VHSTPEGCSS
ACRTIMEIMQ KEALDTKFTE EIPLKILAHN NFVGRLIGKE GRNLKKIEVD TETKITISPL
QDLTLYNPER TITVKGSIEA CSRAEEEVMK KIRESYENDV AAMNGQPESE TVHLFIPALA
VGAIIGKQGQ HIKQLSRFAG ASIKIAPPDS IDTKQRMVII AGPPEAQFKA QGRIFGKLKE
ENFFGPKEEV KLEAHIKVPS FAAGRVIGKG GKTVNELQNL TSAEVVVPRD QTPDENDQVI
VKITGHFYAS QVCYSTTMQ
//
