ID A0A3P8ZM07_ESOLU Unreviewed; 337 AA.
AC A0A3P8ZM07;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sodium/bile acid cotransporter {ECO:0000256|PIRNR:PIRNR026166};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000005964.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Ensembl:ENSELUP00000005964.2, ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000005964.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Does not show transport activity towards bile acids or
CC steroid sulfates. {ECO:0000256|PIRNR:PIRNR026166}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR026166}.
CC Endoplasmic reticulum membrane {ECO:0000256|PIRNR:PIRNR026166}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004394}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528,
CC ECO:0000256|PIRNR:PIRNR026166}.
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DR AlphaFoldDB; A0A3P8ZM07; -.
DR Ensembl; ENSELUT00000009750.2; ENSELUP00000005964.2; ENSELUG00000006934.2.
DR GeneTree; ENSGT00390000011932; -.
DR Proteomes; UP000265140; LG24.
DR Bgee; ENSELUG00000006934; Expressed in nose and 14 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR016833; Put_Na-Bile_cotransptr.
DR PANTHER; PTHR18640:SF5; SODIUM_BILE ACID COTRANSPORTER 7; 1.
DR PANTHER; PTHR18640; SOLUTE CARRIER FAMILY 10 MEMBER 7; 1.
DR Pfam; PF13593; SBF_like; 1.
DR PIRSF; PIRSF026166; UCP026166; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR026166};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR026166};
KW Ion transport {ECO:0000256|PIRNR:PIRNR026166};
KW Membrane {ECO:0000256|PIRNR:PIRNR026166, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW Sodium {ECO:0000256|PIRNR:PIRNR026166};
KW Sodium transport {ECO:0000256|PIRNR:PIRNR026166};
KW Symport {ECO:0000256|PIRNR:PIRNR026166};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|PIRNR:PIRNR026166}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 337 AA; 37021 MW; D36713F4D84A54FD CRC64;
MGLLARVRKE WFIIGIVTVI MLAKIQPSIG AKGGPLRPEI TITFVAVSAI FFNSGLSLKT
EELTSAVLHV KLHLFVQSFT LVFFPLAMWL LIKVLALTSI NTWLLSGLQT VGCMPPPVSS
AVILTKAVGG NEAAAIFNSA FGSFLGIVVT PLLLLLFLGS SSSVSFSSIF SQLFMTVVVP
LILGQVVRRF LKDWLERRKP PFGVISSVVL LMIIYTTFCD TFSNPSIDLD HLSLLLITLI
IFSIQLSFML LTFVLSTQKQ SGFTSADTVA IMFCATHKSL TLGIPMLKIV FEGYDHLSLI
SVPLLIYHPA QILLGSILVP TIQTWMNRRH KPNLLLK
//
